Genetics of mouse behavior: Interactions with laboratory environment

被引：1258

作者：

Crabbe, JC ^{[1
]}

Wahlsten, D

Dudek, BC

机构：

[1] Vet Affairs Med Ctr, Portland Alcohol Res Ctr, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA

[3] Univ Alberta, Dept Psychol, Edmonton, AB T6G 2E9, Canada

[4] SUNY Albany, Dept Psychol, Albany, NY 12222 USA

来源：

SCIENCE | 1999年 / 284卷 / 5420期

关键词：

D O I：

10.1126/science.284.5420.1670

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Strains of mice;that:show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the Laboratory environment were studied in several inbred strains and one null mutant by:simultaneous testing in three Laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across Labs. For some tests, the magnitude of genetic differences depended upon the specific testing Lab.. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular Laboratory.

引用

页码：1670 / 1672

页数：3

共 16 条

[1] VOLUNTARY CONSUMPTION OF ETHANOL IN 15 INBRED MOUSE STRAINS [J].

BELKNAP, JK ;

CRABBE, JC ;

YOUNG, ER .

PSYCHOPHARMACOLOGY, 1993, 112 (04) :503-510

[2]

Cohen J., 1988, STAT POWER ANAL

[3] BIPHASIC EFFECTS OF ETHANOL ON OPEN-FIELD ACTIVITY - SENSITIVITY AND TOLERANCE IN C57BL/6N AND DBA/2N MICE [J].

CRABBE, JC ;

JOHNSON, NA ;

GRAY, DK ;

KOSOBUD, A ;

YOUNG, ER .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1982, 96 (03) :440-451

[4] DISTINCTIONS AMONG SEDATIVE, DISINHIBITORY, AND ATAXIC PROPERTIES OF ETHANOL IN INBRED AND SELECTIVELY BRED MICE [J].

DUDEK, BC ;

PHILLIPS, TJ .

PSYCHOPHARMACOLOGY, 1990, 101 (01) :93-99

[5] A SIMPLE GENETIC-BASIS FOR A COMPLEX PSYCHOLOGICAL TRAIT IN LABORATORY MICE [J].

FLINT, J ;

CORLEY, R ;

DEFRIES, JC ;

FULKER, DW ;

GRAY, JA ;

MILLER, S ;

COLLINS, AC .

SCIENCE, 1995, 269 (5229) :1432-1435

[6] Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype? [J].

Gerlai, R .

TRENDS IN NEUROSCIENCES, 1996, 19 (05) :177-181

[7]

LASALLE JM, 1992, TECHNIQUES GENETIC A, P391

[8]

MCCLEARN GE, 1959, Q J STUD ALCOHOL, V20, P691

[9]

MITCHELL SA, UNPUB

[10] The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth [J].

Nguyen, MT ;

Camenisch, T ;

Snouwaert, JN ;

Hicks, E ;

Coffman, TM ;

Anderson, PAW ;

Malouf, MN ;

Koller, BH .

NATURE, 1997, 390 (6655) :78-81

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