High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection

被引：6

作者：

Peinhardt, GP ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Fac Pharm, Inst Pharmaceut Chem, D-06120 Halle, Germany

来源：

JOURNAL OF CHROMATOGRAPHY B | 1999年 / 726卷 / 1-2期

关键词：

pholedrine;

D O I：

10.1016/S0378-4347(99)00068-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The method for the quantitation of pholedrine in human serum involves extraction of the sample with benzene utilizing an ion-pairing reagent, bis(2-ethylhexyl)phosphoric acid, and re-extraction into diluted phosphoric acid. Analysis is carried out on a ODS reversed-phase column with heptanesulfonate as the ion-pairing reagent. The procedure allows quantitation at the lower nanogram level and is useful for pharmacokinetic investigations. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：309 / 312

页数：4

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