MightyScreen: An Open-Source Visualization Application for Screening Data Analysis

被引:2
作者
Wang, Longfei [1 ]
Yang, Qin [1 ]
Jaimes, Adriana [1 ]
Wang, Tianyu [2 ]
Strobelt, Hendrik [3 ]
Chen, Jenny [4 ]
Sliz, Piotr [1 ]
机构
[1] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02021 USA
[2] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA
[3] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[4] Broad Inst MIT & Harvard, Cambridge, MA USA
关键词
hit selection; visualization; interactive visualization; screening; open source; HIGH-THROUGHPUT; HIT SELECTION; NORMALIZATION; ASSAYS;
D O I
10.1177/2472555217731983
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Screening is a methodology widely used in biological and biomedical research. There are numerous visualization methods to validate screening data quality but very few visualization applications capable of hit selection. Here, we present MightyScreen (mightyscreen.net), a novel web-based application designed for visual data evaluation as well as visual hit selection. We believe MightyScreen is an intuitive and interactive addition to conventional hit selection methods. We also provide study cases showing how MightyScreen is used to visually explore screening data and make hit selections.
引用
收藏
页码:218 / 223
页数:6
相关论文
共 17 条
[1]  
[Anonymous], 2009, SIGKDD Explor Newsl, DOI [10.1145/1656274.1656280, DOI 10.1145/1656274.1656280]
[2]   Academic screening goes high-throughput [J].
Baker, Monya .
NATURE METHODS, 2010, 7 (10) :787-792
[3]   openBIS: a flexible framework for managing and analyzing complex data in biology research [J].
Bauch, Angela ;
Adamczyk, Izabela ;
Buczek, Piotr ;
Elmer, Franz-Josef ;
Enimanev, Kaloyan ;
Glyzewski, Pawel ;
Kohler, Manuel ;
Pylak, Tomasz ;
Quandt, Andreas ;
Ramakrishnan, Chandrasekhar ;
Beisel, Christian ;
Malmstroem, Lars ;
Aebersold, Ruedi ;
Rinn, Bernd .
BMC BIOINFORMATICS, 2011, 12
[4]   Improved statistical methods for hit selection in high-throughput screening [J].
Brideau, C ;
Gunter, B ;
Pikounis, B ;
Liaw, A .
JOURNAL OF BIOMOLECULAR SCREENING, 2003, 8 (06) :634-647
[5]   Phaedra, a Protocol-Driven System for Analysis and Validation of High-Content Imaging and Flow Cytometry [J].
Cornelissen, Frans ;
Cik, Miroslav ;
Gustin, Emmanuel .
JOURNAL OF BIOMOLECULAR SCREENING, 2012, 17 (04) :496-508
[6]   High-throughput screening goes to school [J].
Dove, Alan .
NATURE METHODS, 2007, 4 (06) :523-529
[7]   Screening Technologies for Small Molecule Discovery: The State of the Art [J].
Janzen, William P. .
CHEMISTRY & BIOLOGY, 2014, 21 (09) :1162-1170
[8]   An efficient method for the detection and elimination of systematic error in high-throughput screening [J].
Makarenkov, Vladimir ;
Zentilli, Pablo ;
Kevorkov, Dmytro ;
Gagarin, Andrei ;
Malo, Nathalie ;
Nadon, Robert .
BIOINFORMATICS, 2007, 23 (13) :1648-1657
[9]   Statistical practice in high-throughput screening data analysis [J].
Malo, N ;
Hanley, JA ;
Cerquozzi, S ;
Pelletier, J ;
Nadon, R .
NATURE BIOTECHNOLOGY, 2006, 24 (02) :167-175
[10]   Rank Ordering Plate Data Facilitates Data Visualization and Normalization in High-Throughput Screening [J].
Mangat, Chand S. ;
Bharat, Amrita ;
Gehrke, Sebastian S. ;
Brown, Eric D. .
JOURNAL OF BIOMOLECULAR SCREENING, 2014, 19 (09) :1314-1320