Influence of grape variety and their phenolic composition on vasorelaxing activity of young red wines

被引：16

作者：

Ortega, Teresa ^{[1
]}

De La Hera, Elena ^{[1
]}

Emilia Carretero, M. ^{[1
]}

Gomez-Serranillos, Pilar ^{[1
]}

Victoria Naval, M. ^{[1
]}

Villar, Angel M. ^{[1
]}

Prodanov, Marin ^{[2
]}

Vacas, Visitacion ^{[2
]}

Arroyo, Teresa ^{[2
]}

Hernandez, Teresa ^{[3
]}

Estrella, Isabel ^{[3
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Farmacol, E-28040 Madrid, Spain

[2] Inst Madrileno Invest & Desarrollo Rural Agr & Al, Dept Agroalimentac, Madrid 28800, Spain

[3] CSIC, Inst Fermentac Ind, E-28006 Madrid, Spain

来源：

EUROPEAN FOOD RESEARCH AND TECHNOLOGY | 2008年 / 227卷 / 06期

关键词：

young monovarietal wine; Merlot; Tempranillo; Garnacha; Cabernet-Sauvignon; phenolic composition; vasorelaxation; vasoprotective;

D O I：

10.1007/s00217-008-0888-9

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Red wine has been reported to exert beneficial effects in preventing cardiovascular diseases probably due to their polyphenols constituents. The vasorelaxant capacity and phenolic composition of four monovarietal young red wines Merlot, Tempranillo, Garnacha and Cabernet-Sauvignon obtained from grapes from 2004 vintage, cultivated under the same climatic and agricultural conditions, wine-making technology and storage conditions, were determined using vascular reactivity assay in rat aortic and high-performance liquid chromatography, respectively. Primary cultures of vascular smooth muscle cells from Wistar rats were also used to evaluate their survival prevention activity as well. Every studied wine present vasorelaxation effect, but the higher value corresponds to the analyzed Merlot wine, especially rich in phenolic compounds, mainly catechins and oligomeric proanthocyanidins and anthocyanin glycosides. This study further demonstrated previous investigations about the phenolic composition of wines relation with their vasorelaxation activity.

引用

页码：1641 / 1650

页数：10

共 58 条

[1] Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS [J].

Anselm, Eric ;

Chataigneau, Marta ;

Ndiaye, Mamadou ;

Chataigneau, Thierry ;

Schini-Kerth, Valerie B. .

CARDIOVASCULAR RESEARCH, 2007, 73 (02) :404-413

[2] BITTERNESS AND ASTRINGENCY OF PHENOLIC FRACTIONS IN WINE [J].

ARNOLD, RA ;

NOBLE, AC ;

SINGLETON, VL .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1980, 28 (03) :675-678

[3]

Arts ICW, 2005, AM J CLIN NUTR, V81, p317S, DOI 10.1093/ajcn/81.1.317S

[4] PHOTODIODE-ARRAY DETECTION FOR ELUCIDATION OF THE STRUCTURE OF PHENOLIC-COMPOUNDS [J].

BARTOLOME, B ;

BENGOECHEA, ML ;

GALVEZ, MC ;

PEREZILZARBE, FJ ;

HERNANDEZ, T ;

ESTRELLA, I ;

GOMEZCORDOVES, C .

JOURNAL OF CHROMATOGRAPHY A, 1993, 655 (01) :119-125

[5] Determination of some structural features of procyanidins and related compounds by photodiode-array detection [J].

Bartolome, B ;

Hernandez, T ;

Bengoechea, ML ;

Quesada, C ;

GomezCordoves, C ;

Estrella, I .

JOURNAL OF CHROMATOGRAPHY A, 1996, 723 (01) :19-26

[6]

BEDOUI J, 2005, CARDIOVASC RES, V67, P317

[7] STRUCTURE OF HYDROXYCINNAMIC ACID-DERIVATIVES ESTABLISHED BY HIGH-PERFOMANCE LIQUID-CHROMATOGRAPHY WITH PHOTODIODE-ARRAY DETECTION [J].

BENGOECHEA, L ;

HERNANDEZ, T ;

QUESADA, C ;

BARTOLOME, B ;

ESTRELLA, I ;

GOMEZCORDOVES, C .

CHROMATOGRAPHIA, 1995, 41 (1-2) :94-98

[8]

Berti F, 2003, DRUG EXP CLIN RES, V29, P207

[9]

Booyse FM, 2001, THROMB HAEMOSTASIS, V86, P517

[10] Wine, diet, and arterial hypertension [J].

Carollo, Caterina ;

Lo Presti, Rosalia ;

Caimi, Gregorio .

ANGIOLOGY, 2007, 58 (01) :92-96

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