Recurrent pleural effusion (RPE) can be encountered in various benign conditions such as inflammatory, infectious, or other systemic diseases (e.g., congestive heart failure (CHF), hepatic hydrothorax, post lung transplants, post coronary artery bypass graft (CABG) surgery, and chronic exudative pleurisy). Each condition is treated based on its unique pathophysiologic characteristics, and medical management is successful in the majority of patients. In rare circumstances, pleural effusions are rapidly recurring despite optimal medical therapy and patients have frequent hospitalisations that require repeated thoracenteses. Other than medical therapy and repeat thoracentesis, treatment options are limited to chest tube placement and chemical pleurodesis or, rarely, surgical pleurodesis. We conducted a literature review using PubMed and Google Scholar, finding 33 articles that were relevant to our topic over the last 30 years. In patients with recurrent benign pleural effusion that is refractory to medical management, the PleurX catheter seems to be a useful tool in relieving respiratory symptoms, decreasing the rate of hospitalisation and achieving pleurodesis. (Heart, Lung and Circulation 2012;21:661-665) (C) 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier Inc. All rights reserved.