Evolution in Our Understanding of Hepatitis B Virus Virology and Immunology

被引：23

作者：

Bengsch, Bertram ^{[1
,2
]}

Chang, Kyong-Mi ^{[3
,4
]}

机构：

[1] Univ Penn, Dept Microbiol, Perelman Sch Med, 331 Biomed Res Bldg 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Immunol, Perelman Sch Med, 331 Biomed Res Bldg 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA

[3] Philadelphia Corporal Michael J Crescenz VA Med C, Med Res, A424 Univ & Woodland Ave, Philadelphia, PA 19104 USA

[4] Univ Penn, Perelman Sch Med, Dept Med, Div Gastroenterol, 421 Curie Blvd, Philadelphia, PA 19104 USA

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 04期

关键词：

Hepatitis B virus; Pathogenesis; Translational hepatology; cccDNA; Immunobiology; Immunotherapy; B and T cell responses to HBV; Therapeutic vaccination; CD8(+) T-CELLS; ADAPTIVE IMMUNE-RESPONSES; AUSTRALIA-ANTIGEN; VIRAL-HEPATITIS; HEPATOCELLULAR-CARCINOMA; REVERSE TRANSCRIPTION; FUNCTIONAL DICHOTOMY; ANTIVIRAL IMMUNITY; PROGRAMMED DEATH-1; INFECTED-CELLS;

D O I：

10.1016/j.cld.2016.06.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis B virus (HBV) infection is a major global health challenge. HBV can cause significant morbidity and mortality by establishing acute and chronic hepatitis. Approximately 250 million people worldwide are chronically infected, and more than 2 billion people have been exposed to HBV. Since the discovery of HBV, the advances in our understanding of HBV virology and immunology have translated into effective vaccines and therapies for HBV infection. Although current therapies successfully suppress viral replication but rarely succeed in viral eradication, recent discoveries in HBV virology and immunology provide exciting rationales for novel treatment strategies aiming at HBV cure.

引用

页码：629 / +

页数：17