Melaleuca alternifolia (tea tree) oil and its monoterpene constituents in treating protozoan and helminthic infections

被引：44
作者：
Lam, Nelson Siukei [1 ,5 ]
Long, Xinxin [1 ]
Su, Xin-zhuan [2 ]
Lu, Fangli [3 ,4 ]
机构：
[1] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
[2] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20854 USA
[3] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Parasitol, Guangzhou 510080, Peoples R China
[4] Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Peoples R China
[5] Univ Adelaide, Fac Hlth & Sci, Adelaide, SA, Australia
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 130卷
基金：
美国国家卫生研究院;
关键词：
Melaleuca alternifolia; Tea tree oil; Protozoa; Nematodes; Cestode; Monogenean parasites; IN-VITRO; ICHTHYOPHTHIRIUS-MULTIFILIIS; ANTHELMINTIC ACTIVITY; PARASITE DEVELOPMENT; SILVER CATFISH; EIMERIA SPP; TERPINEN-4-OL; RESISTANCE; DRUG; ACTIVATION;
D O I：
10.1016/j.biopha.2020.110624
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Australian tea tree (Melaleuca alternifolia) oil (TTO) and its monoterpene constituents such as terpinen-4-ol (T4O), 1,8-cineole, limonene, p-cymene, and a-terpinene have been shown to be effective in controlling a wide range of parasitic infections. The anti-parasitic effects of these compounds are mainly due to their anti-histamine and anti-acetylcholinesterase activities as well as their ability to modulate host inflammatory responses. This review attempts to summarize recent advances in the uses of TTO and its 15 major monoterpene constituents in treating parasitic infections in both humans and animals. Activities against parasitic protozoans (Plasmodium falciparum, Leishmania spp., Trypanosoma spp., Acanthamoeba castellanii, Trichomonas vaginalis, Eimeria, and Ichthyophthirius multifiliis), nematodes (Haemonchus contortus and Anisakis simplex), cestode (Echinococcus ortleppi), and monogeneans (Gasterosteus spp. and Dactylogyrus minutus) have been reported, showing good potentials in treating parasitic infections. Further studies are necessary for developing anti-parasite therapies using TTO or its monoterpenes constituents.
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页数：13
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