Sustained Delivery of Hydrocortisone Acetate by CS/N-Vinyl-2-Pyrrolidone/CaCO3 Microparticle Hybrid Hydrogels

被引：2

作者：

Mostafa, Tahia B. ^{[1
]}

El-Sigeny, Samia ^{[2
]}

Abou Taleb, Manal F. ^{[3
,4
]}

机构：

[1] Ain Shams Univ, Coll Women, Cairo, Egypt

[2] Kafrelsheikh Univ, Dept Chem, Fac Sci, Kafr Al Sheikh 33516, Egypt

[3] Salman Bin Abdul Aziz Univ, Fac Sci & Humanities, Dept Chem, Alkharj, Saudi Arabia

[4] Natl Ctr Radiat Res & Technol, Dept Polymer Chem, Cairo, Egypt

来源：

POLYMER COMPOSITES | 2014年 / 35卷 / 06期

关键词：

CALCIUM-CARBONATE; RADIATION SYNTHESIS; RELEASE; NANOPARTICLES; ENCAPSULATION; SCAFFOLDS; CHITOSAN; STYRENE; ACID; PH;

D O I：

10.1002/pc.22765

中图分类号：

TB33 [复合材料];

学科分类号：

摘要：

The goal of this research is to develop a composite hydrogel system for sustained release of therapeutic agents. The hybrid hydrogels were prepared by radiation crosslinking on aqueous solution of Chitosan (CS)/N-vinyl-2-pyrrolidone (NVP) with different loads of CaCO3 in the presence of hydrocortisone acetate (HCA), an anti-inflammatory drugs. Physical characteristics of CS/NVP/CaCO3 were studied using X-ray diffraction (XRD) and infrared spectrophotometery (IR). The porous structure of resulted hydrogel was confirmed by SEM micrographs. The effect of doses and calcium carbonate amount on the swelling of the hydrogels was investigated. The ability of the prepared CS/NVP/CaCO3-based hybrid hydrogels to be used as drug carriers for anti-inflammatory-specific drug delivery system was estimated using HCA as a model drug. POLYM. COMPOS., 35:1176-1183, 2014. (c) 2013 Society of Plastics Engineers

引用

页码：1176 / 1183

页数：8

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