A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release

被引：19

作者：

Huang, Yu ^{[1
,2
]}

Shen, Lingyue ^{[3
,4
]}

Guo, Dongbo ^{[1
]}

Yasen, Wumaier ^{[1
]}

Wu, Yan ^{[1
]}

Su, Yue ^{[1
]}

Chen, Dong ^{[1
]}

Qiu, Feng ^{[3
,4
,5
]}

Yan, Deyue ^{[1
]}

Zhu, Xinyuan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China

[2] Imperial Coll London, Dept Chem Engn, South Kensington Campus, London SW7 2AZ, England

[3] Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai Peoples Hosp 9,Shanghai Key Lab Stomatol, Sch Med,Dept Laser & Aesthet Med,Natl Clin Res Ct, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[5] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 47期

基金：

中国国家自然科学基金;

关键词：

ANTICANCER DRUG; DELIVERY; NANOPARTICLES; POLYMERS;

D O I：

10.1039/c9cc02901j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A near-infrared (NIR)-sensitive gated assembly of supramolecular conjugated unimicelles based on robust host-guest recognition between a beta-cyclodextrin-grafted hyperbranched conjugated polymer and azobenzene-functionalized poly(ethylene glycol) was constructed. Utilized as a drug carrier, these unimicelles exhibited controlled drug release through the NIR-triggered photoisomerization of azobenzene in cancer cells via a two-photon excited fluorescence resonance energy transfer (TP-FRET) approach, leading to efficient cancer therapy.

引用

页码：6735 / 6738

页数：4