A NIR-triggered gatekeeper of supramolecular conjugated unimicelles with two-photon absorption for controlled drug release

被引：19
|
作者：
Huang, Yu [1 ,2 ]
Shen, Lingyue [3 ,4 ]
Guo, Dongbo [1 ]
Yasen, Wumaier [1 ]
Wu, Yan [1 ]
Su, Yue [1 ]
Chen, Dong [1 ]
Qiu, Feng [3 ,4 ,5 ]
Yan, Deyue [1 ]
Zhu, Xinyuan [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China
[2] Imperial Coll London, Dept Chem Engn, South Kensington Campus, London SW7 2AZ, England
[3] Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai Peoples Hosp 9,Shanghai Key Lab Stomatol, Sch Med,Dept Laser & Aesthet Med,Natl Clin Res Ct, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[5] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 47期
基金：
中国国家自然科学基金;
关键词：
ANTICANCER DRUG; DELIVERY; NANOPARTICLES; POLYMERS;
D O I：
10.1039/c9cc02901j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A near-infrared (NIR)-sensitive gated assembly of supramolecular conjugated unimicelles based on robust host-guest recognition between a beta-cyclodextrin-grafted hyperbranched conjugated polymer and azobenzene-functionalized poly(ethylene glycol) was constructed. Utilized as a drug carrier, these unimicelles exhibited controlled drug release through the NIR-triggered photoisomerization of azobenzene in cancer cells via a two-photon excited fluorescence resonance energy transfer (TP-FRET) approach, leading to efficient cancer therapy.
引用
收藏
页码：6735 / 6738
页数：4
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