Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity

被引：24

作者：

Akisaka, M ^{[1
]}

Suzuki, M ^{[1
]}

Inoko, H ^{[1
]}

机构：

[1] TOKAI UNIV,SCH MED,DIV MOL LIFE SCI,DEPT GENET INFORMAT,HIRATSUKA,KANAGAWA 25912,JAPAN

来源：

TISSUE ANTIGENS | 1997年 / 50卷 / 05期

关键词：

centenarian; HLA-DQ; HLA-DR; linkage disequilibrium; longevity; major histocompatibility complex (MHC); Okinawa; polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP);

D O I：

10.1111/j.1399-0039.1997.tb02904.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Okinawan Japanese are well known for their longevity; the population rate of centenarians in Okinawa is about 3.8 times higher than that of the whole Japan, where the average life expectancies both among men and among women are the highest in the world. In this study, we analyzed HLA class II alleles of Okinawan centenarians by the polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) method for the purpose of clarifying the presence of primary genetic factors in the major histocompatibility complex (MHC) region associated with human iongevity. DRB1*1401, DQB1*0503, DQA1*0101=0104 and DQA1*05 were significantly increased in the centenarians. The significant increase of HLA-DQB1*0503 and/or DQA1*0101=0104 in the centenarians can be explained by a linkage disequilibrium with DRB1*1401, or vice versa. Further, the tendency was observed toward increase with respect to DRB1*0101 and DRB1*1201. These data suggest that several alleles of the HLA-DRB1 and/or HLA-DQ genes are involved in human longevity.

引用

页码：489 / 493

页数：5

共 17 条

[1]

AKAZA T, 1994, MHC IRS S, V1, P219

[2]

[Anonymous], WORLD HLTH STAT ANN

[3]

BOCHXMEER FM, 1994, NAT GENET, V6, P4

[4]

*GOV OK PREF, 1995, VER REC LONG OK PREF

[5]

IMANISHI T, 1992, P 11 INT HIST WORKSH, V1, P1065

[6] SOUTHERN HYBRIDIZATION ANALYSIS OF DNA POLYMORPHISM IN THE HLA-D REGION [J].

INOKO, H ;

ANDO, A ;

ITO, M ;

TSUJI, K .

HUMAN IMMUNOLOGY, 1986, 16 (03) :304-313

[7]

INOKO H, 1993, HDB HLA TYPING TECHN, P9

[8]

MAEDA H, 1994, MHC IRS S, V1, P214

[9]

*MIN HLTH WELF, 1996, LIST EXTR AG 1996

[10]

*MIN HLTH WELF, 1990, LIF TABL ABR LIF TAB

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