A receptor for green tea polyphenol EGCG

被引：565

作者：

Tachibana, H ^{[1
]}

Koga, K ^{[1
]}

Fujimura, Y ^{[1
]}

Yamada, K ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Fukuoka 8128581, Japan

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 04期

关键词：

D O I：

10.1038/nsmb743

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The major polyphenol in green tea, (-) - epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K-d value.

引用

页码：380 / 381

页数：2