Effectiveness and safety of endoscopic aspiration mucosectomy and endoscopic submucosal dissection in patients with superficial esophageal squamous-cell carcinoma

被引：13

作者：

Furue, Yasuaki ^{[1
,2
]}

Katada, Chikatoshi ^{[1
]}

Tanabe, Satoshi ^{[3
]}

Ishido, Kenji ^{[1
]}

Kondo, Yuki ^{[1
]}

Kubota, Yo ^{[1
]}

Kawanishi, Natuko ^{[1
]}

Yamane, Sakiko ^{[1
]}

Watanabe, Akinori ^{[1
]}

Moriya, Hiromitsu ^{[4
]}

Yamashita, Keishi ^{[4
]}

Wada, Takuya ^{[1
]}

Yano, Takafumi ^{[1
]}

Azuma, Mizutomo ^{[1
]}

Koizumi, Wasaburo ^{[1
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Gastroenterol, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520374, Japan

[2] Natl Canc Ctr Hosp East, Dept Gastroenterol & Endoscopy, Kashiwa, Chiba, Japan

[3] Kitasato Univ, Sch Med, Res & Dev Ctr New Frontier, Sagamihara, Kanagawa, Japan

[4] Kitasato Univ, Sch Med, Dept Surg, Sagamihara, Kanagawa, Japan

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2019年 / 33卷 / 05期

基金：

日本学术振兴会;

关键词：

Esophageal squamous-cell carcinoma; Endoscopic aspiration mucosectomy; Endoscopic submucosal dissection; Safety; Efficacy; MUCOSAL RESECTION; EMR; THERAPY;

D O I：

10.1007/s00464-018-6418-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BackgroundEndoscopic submucosal dissection (ESD) has been performed in a high proportion of patients with superficial esophageal squamous-cell carcinoma. Endoscopic aspiration mucosectomy (EAM) is a more straightforward technique that is easier to perform. We retrospectively evaluated the safety and efficacy of EAM and ESD to clarify the advantages and disadvantages of each procedure.MethodsA total of 374 patients (423 lesions) who underwent endoscopic resection were retrospectively studied. The following variables were evaluated (1) procedure time and adverse events as safety, and (2) en bloc complete resection rate, local recurrence rate, lymph node recurrence rate, overall survival rate, and cause-specific survival rate as efficacy.ResultsEAM was performed in 134 patients (149 lesions), and ESD was performed in 240 patients (274 lesions). The procedure times of EAM and ESD were 31.022.4 and 85.7 +/- 46.5min (p<0.001), respectively. The perforation rates were 0 and 6.2% (p=0.002), respectively. The en bloc complete resection rates were 48.3 and 91.6% (p<0.001), respectively. The local recurrence rates were 5.5 and 0% (p<0.001), respectively. For lesions measuring less than 15mm in diameter, EAM had a relatively good en bloc complete resection rate (EAM, 76.1% vs. ESD, 100%) and a significantly short procedure time (EAM, 25.2 +/- 15.2min vs. ESD, 62.7 +/- 35.2min; p<0.001).Conclusionsp id=ParESD has a higher en bloc complete resection rate and a better local control rate than EAM. For lesions measuring less than 15mm in diameter, EAM may be a treatment option.

引用

页码：1433 / 1440

页数：8

共 23 条

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