A sensitizing regimen of methamphetamine causes impairments in a novelty preference task of object recognition

被引：34
作者：
Belcher, Annabelle M. [1 ]
O'Dell, Steven J. [1 ]
Marshall, John F. [1 ]
机构：
[1] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2006年 / 170卷 / 01期
关键词：
rat; sensitization; DAT; SERT;
D O I：
10.1016/j.bbr.2006.02.025
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
A neurotoxic regimen of methamphetamine impairs object recognition (OR) in rats. The present study investigated whether neurotoxicity is a necessary component of methamphetamine's effect on OR. Animals were exposed to a sensitizing regimen of methamphetamine, and were tested for OR one week, and locomotor behavior two weeks, later. Quantitative autoradiography was used to measure [I-125]RTI-55 binding to forebrain dopaminergic and serotonergic transporters. Methamphetamine treatment produced significant OR impairments (and increased locomotion), without reducing dopamine or serotonin transporter binding. This study supports the conclusion that factors other than monoamine terminal injury contribute to the methamphetamine-induced cognitive impairments. (c) 2006 Elsevier B.V. All rights reserved.
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收藏
页码：167 / 172
页数：6
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