Primary Ovarian Insufficiency

被引：797

作者：

Nelson, Lawrence M. ^{[1
]}

机构：

[1] NICHHD, Integrat Reprod Med Unit, Intramural Res Program Reprod & Adult Endocrinol, NIH,CRC, Bethesda, MD 20892 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 06期

关键词：

POSTMENOPAUSAL WOMEN; NATURAL MENOPAUSE; VENOUS THROMBOEMBOLISM; OOCYTE DONATION; YOUNG-WOMEN; FAILURE; AGE; GONADOTROPIN; THERAPY; PREMUTATION;

D O I：

10.1056/NEJMcp0808697

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 30- year- old woman presents with a history of no menses since she stopped taking oral contraceptives 6 months ago in order to conceive. She had undergone puberty that was normal in both timing and development, with menarche at 12 years of age. At 18 years of age, she started taking oral contraceptives for irregular menses. She reports stress at work. Her weight is 59 kg, and her height 1.66 m; her body- mass index ( the weight in kilograms divided by the square of the height in meters) is 21.3. There is no galactorrhea, hirsutism, or acne. The pelvic examination is normal, a pregnancy test is negative, the prolactin level is normal, and the follicle- stimulating hormone ( FSH) level is in the menopausal range. How should she be evaluated and treated?

引用

页码：606 / 614

页数：9

共 59 条

[1] Obstetric outcome in 232 ovum donation pregnancies [J].

Abdalla, HI ;

Billett, A ;

Kan, AKS ;

Baig, S ;

Wren, M ;

Korea, L ;

Studd, JWW .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1998, 105 (03) :332-337

[2] MUTATION IN THE FOLLICLE-STIMULATING-HORMONE RECEPTOR GENE CAUSES HEREDITARY HYPERGONADOTROPIC OVARIAN FAILURE [J].

AITTOMAKI, K ;

LUCENA, JLD ;

PAKARINEN, P ;

SISTONEN, P ;

TAPANAINEN, J ;

GROMOLL, J ;

KASKIKARI, R ;

SANKILA, EM ;

LEHVASLAIHO, H ;

ENGEL, AR ;

NIESCHLAG, E ;

HUHTANIEMI, I ;

DELACHAPELLE, A .

CELL, 1995, 82 (06) :959-968

[3]

Albricht H, 1942, AM J MED SCI, V204, P625

[4] PREGNANCIES AFTER PREMATURE OVARIAN FAILURE [J].

ALPER, MM ;

JOLLY, EE ;

GARNER, PR .

OBSTETRICS AND GYNECOLOGY, 1986, 67 (03) :S59-S62

[5]

American College of Obstetrics and Gynecology, 2006, OBSTET GYNECOL, V107, P1483

[6] Bone loss in young women with karyotypically normal spontaneous premature ovarian failure [J].

Anasti, JN ;

Kalantaridou, SN ;

Kimzey, LM ;

Defensor, RA ;

Nelson, LM .

OBSTETRICS AND GYNECOLOGY, 1998, 91 (01) :12-15

[7] Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure [J].

Bakalov, VK ;

Anasti, JN ;

Calis, KA ;

Vanderhoof, VH ;

Premkumar, A ;

Chen, S ;

Furmaniak, J ;

Smith, BR ;

Merino, MJ ;

Nelson, LM .

FERTILITY AND STERILITY, 2005, 84 (04) :958-965

[8] Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: Markers of low progression to clinical Addison's disease .1. [J].

Betterle, C ;

Volpato, M ;

Smith, BR ;

Furmaniak, J ;

Chen, S ;

Greggio, NA ;

Sanzari, M ;

Tedesco, F ;

Pedini, B ;

Boscaro, M ;

Presotto, F .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (03) :932-938

[9] Adverse endometrial effects during long cycle hormone replacement therapy [J].

Bjarnason, K ;

Cerin, Å ;

Lindgren, R ;

Weber, T .

MATURITAS, 1999, 32 (03) :161-170

[10] Hormone therapy and venous thromboembolism among postmenopausal women -: Impact of the route of estrogen administration and progestogens:: The ESTHER study [J].

Canonico, Marianne ;

Oger, Emmanuel ;

Plu-Bureau, Genevieve ;

Conard, Jacqueline ;

Meyer, Guy ;

Levesque, Herve ;

Trillot, Nathalie ;

Barrellier, Marie-Therese ;

Wahl, Denis ;

Emmerich, Joseph ;

Scarabin, Pierre-Yves .

CIRCULATION, 2007, 115 (07) :840-845

← 1 2 3 4 5 6 →