Discovery of thiophene inhibitors of polo-like kinase

被引：38

作者：

Emmitte, Kyle A. ^{[1
]}

Andrews, C. Webb ^{[1
]}

Badiang, Jennifer G. ^{[1
]}

Davis-Ward, Ronda G. ^{[1
]}

Dickson, Hamilton D. ^{[1
]}

Drewry, David H. ^{[1
]}

Emerson, Holly K. ^{[1
]}

Epperly, Andrea H. ^{[1
]}

Hassler, Daniel F. ^{[1
]}

Knick, Victoria B. ^{[1
]}

Kuntz, Kevin W. ^{[1
]}

Lansing, Timothy J. ^{[1
]}

Linn, James A. ^{[1
]}

Mook, Robert A., Jr. ^{[1
]}

Nailor, Kristen E. ^{[1
]}

Salovich, James M. ^{[1
]}

Spehar, Glenn M. ^{[1
]}

Cheung, Mui ^{[1
]}

机构：

[1] GlaxoSmithKline, Oncol R & D, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Thiophene; Benzimidazole; Polo-like kinase; Mitosis; Inhibitor; Cell-cycle; PLK1;

D O I：

10.1016/j.bmcl.2008.11.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1018 / 1021

页数：4

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