Hepatitis B reactivation in a patient with rheumatoid arthritis with antibodies to hepatitis B surface antigen treated with rituximab.

被引：0
作者：
Gigi, E. [1 ]
Georgiou, T. [1 ]
Sarantopoulos, A. [2 ]
Mougiou, D. [3 ]
Boura, P. [2 ]
Raptopoulou-Gigi, M. [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Hippokratio Hosp, Dept Internal Med 2, Liver Unit,Med Sch, GR-54006 Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Clin Immunol Unit, Dept Internal Med 2, Hippokratio Hosp,Med Sch, GR-54006 Thessaloniki, Greece
[3] Aristotle Univ Thessaloniki, Dept Clin Microbiol, Sch Med, GR-54006 Thessaloniki, Greece
来源：
HIPPOKRATIA | 2013年 / 17卷 / 01期
关键词：
HBV reactivation; rituximab; rheumatoid arthritis; monoclonal antibodies; VIRUS HBV REACTIVATION; PREVENTION; MANAGEMENT; CHEMOTHERAPY; STATEMENT;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatitis B virus (HBV) can still be found within the hepatocytes after its clearance and the control of viral replication depends on the immune response. However during immunosuppression, seroconversion of HBsAg has been described followed by disease reactivation. Hepatitis B virus reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents and in particular, by the use of rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and long-lasting immunosuppression. We describe a case of a 64-year old female patient with rheumatoid arthritis and resolved HBV infection, who experienced a severe hepatitis B reactivation after the administration of rituximab.
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页码：91 / 93
页数：3
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