Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content

被引：23
作者：
Cassano, P.
Sciancalepore, A. G.
Lezza, A. M. S.
Leeuwenburgh, C.
Cantatore, P.
Gadaleta, M. N.
机构：
[1] Univ Bari, Dept Biochem & Mol Biol, I-70125 Bari, Italy
[2] Univ Florida, Coll Med, Dept Aging & Geriatr Res, Biochem Aging Lab, Gainesville, FL USA
[3] CNR, Inst Biomembranes & Bioenerget, I-70126 Bari, Italy
来源：
REJUVENATION RESEARCH | 2006年 / 9卷 / 02期
关键词：
D O I：
10.1089/rej.2006.9.211
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The effect of age and caloric-restriction (CR) diet on mitochondrial DNA (mtDNA) content in different rat tissues was investigated. A decrease of the mtDNA content occurs with aging in liver and soleus muscle, whereas there is no age-related significant change of mtDNA content in brain. CR fully reverses the age-dependent loss of mtDNA in liver and soleus, whereas it results in a significant increase of mtDNA amount above the value of aged ad libitum fed rats in brain. These results further support the tissue-specific effect of CR, likely because of the different dependence of tissues on external nutrient uptake.
引用
收藏
页码：211 / 214
页数：4
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共 15 条
  • [1] Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle
    Aspnes, LE
    Lee, CM
    Weindruch, R
    Chung, SS
    Roecker, EB
    Aiken, JM
    [J]. FASEB JOURNAL, 1997, 11 (07) : 573 - 581
  • [2] Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart
    Barazzoni, R
    Short, KR
    Nair, KS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) : 3343 - 3347
  • [3] Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle
    Bua, EA
    McKiernan, SH
    Aiken, JM
    [J]. FASEB JOURNAL, 2004, 18 (01) : 582 - +
  • [4] Mitochondrial free radical generation, oxidative stress, and aging
    Cadenas, E
    Davies, KJA
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (3-4) : 222 - 230
  • [5] Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet
    Cassano, P
    Lezza, AMS
    Leeuwenburgh, C
    Cantatore, P
    Gadaleta, MN
    [J]. STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE, 2004, 1019 : 269 - 273
  • [6] Mitochondrial abnormalities in muscle and other aging cells: Classification, causes, and effects
    DiMauro, S
    Tanji, K
    Bonilla, E
    Pallotti, F
    Schon, EA
    [J]. MUSCLE & NERVE, 2002, 26 (05) : 597 - 607
  • [7] Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
    Gredilla, R
    Sanz, A
    Lopez-Torres, M
    Barja, G
    [J]. FASEB JOURNAL, 2001, 15 (07) : 1589 - +
  • [8] Age-related mitochondrial DNA deletions: Effect of dietary restriction
    Kang, CM
    Kristal, BS
    Yu, BP
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1998, 24 (01) : 148 - 154
  • [9] Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria
    López-Torres, M
    Gredilla, R
    Sanz, A
    Barja, G
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2002, 32 (09) : 882 - 889
  • [10] Early-onset calorie restriction conserves fiber number in aging rat skeletal muscle
    McKiernan, S
    Bua, E
    McGorray, J
    Aiken, J
    [J]. FASEB JOURNAL, 2004, 18 (01) : 580 - +
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