Tear Film Osmolarity in Patients with Diabetes Mellitus

被引：44

作者：

Sagdik, H. Murat ^{[1
]}

Tetikoglu, Mehmet ^{[1
]}

Ucar, Fatma ^{[2
]}

Ugurbas, Silay Canturk ^{[3
]}

Ugurbas, Suat Hayri ^{[3
]}

机构：

[1] Mus State Hosp, Inst Eye, Mus, Turkey

[2] Etlik Educ & Res Hosp, Dept Biochem, Ankara, Turkey

[3] Karaelmas Univ, Fac Med, Dept Ophthalmol, Zonguldak, Turkey

来源：

OPHTHALMIC RESEARCH | 2013年 / 50卷 / 01期

关键词：

Tear film osmolarity; Glycosylated hemoglobin; Diabetes mellitus; OCULAR SURFACE CHANGES; DRY EYE DISEASE; SECRETION; INSTABILITY;

D O I：

10.1159/000345770

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. Methods: In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in millios-mole (mOsm) was measured by using an auto-osmometer. The serum levels of glycosylated hemoglobin (HbA(1)c) and blood glucose in all participants were also measured. Mean outcome measures were TFO and its relationship with HbA(1)c level and duration of DM. Results: Mean TFO was 320.40 +/- 21.80 mOsm/l in the study group and 308.22 +/- 18.16 mOsm/l in the control group (p < 0.001). The TFO values were significantly associated with duration of DM (r = 0.476, p < 0.001), but no significant correlation was found with HbA(1)c level (r = 0.225, p = 0.114). Conclusions: The study shows a significantly higher TFO in patients with DM than in the healthy controls. TFO also correlates with the duration of DM. copyright (C) 20135. Karger AG, Basel

引用

页码：1 / 5

页数：5

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