Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles

被引：114

作者：

Venkatasubbu, G. Devanand ^{[1
]}

Ramasamy, S. ^{[1
]}

Avadhani, G. S. ^{[2
]}

Ramakrishnan, V. ^{[3
]}

Kumar, J. ^{[1
]}

机构：

[1] Anna Univ, Ctr Crystal Growth, Madras 600025, Tamil Nadu, India

[2] Indian Inst Sci, Dept Mat Engn, Bangalore 560012, Karnataka, India

[3] Madurai Kamaraj Univ, Sch Phys, Dept Laser Studies, Madurai 625021, Tamil Nadu, India

来源：

POWDER TECHNOLOGY | 2013年 / 235卷

关键词：

Hydroxyapatite nanoparticles; PEG; Folic acid; Drug targeting; Paclitaxel; IN-VIVO; RELEASE; MATRIX;

D O I：

10.1016/j.powtec.2012.11.003

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Nanoparticles are used for a number of biomedical applications. In this work we report the synthesis of folic acid (FA) modified polyethylene glycol (PEG) functionalized hydroxyapatite (HAp) nanoparticles. The anticancer drug, paclitaxel, is attached to the folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles and the in vitro drug release is analyzed. The surface modification and functionalization is confirmed by Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA) and UV spectroscopy. The importance of the paper is the investigation of the release behavior of paclitaxel conjugated folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. The results show an initial rapid release and then a sustained release. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：437 / 442

页数：6

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