Highly regio- and stereo-selective alkylsubstitution with copper reagents for the construction of chiral trifluoromethylated quaternary carbon centres

被引：24

作者：

Hiraoka, S ^{[1
]}

Yamazaki, T ^{[1
]}

Kitazume, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 226,JAPAN

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 16期

关键词：

D O I：

10.1039/a703223d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new route for the asymmetric construction of quaternary carbon centres containing a trifluoromethyl group has been established using a highly regio-and stereo-selective S(N)2' reaction of organocopper and organocuprate reagents with allylic mesylates 4 and 8.

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收藏

页码：1497 / 1498

页数：2

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