Chiral Phosphoric Acid-Catalyzed Oxidative Kinetic Resolution of Indolines Based on Transfer Hydrogenation to Imines

被引：112

作者：

Saito, Kodai ^{[1
]}

Shibata, Yukihiro ^{[2
,3
]}

Yamanaka, Masahiro ^{[2
,3
]}

Akiyama, Takahiko ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

[2] Rikkyo Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718501, Japan

[3] Rikkyo Univ, Fac Sci, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 32期

关键词：

BETA-HYDROXY AMINES; FRIEDEL-CRAFTS REACTIONS; ASYMMETRIC HYDROGENATION; SECONDARY ALCOHOLS; REDUCTIVE AMINATION; MOLECULAR-OXYGEN; BENZOTHIAZOLINE; ENANTIOSELECTIVITY; DFT; MECHANISM;

D O I：

10.1021/ja406004q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The oxidative kinetic resolution of 2-substituted indoline derivatives was achieved by hydrogen transfer to imines by means of a chiral phosphoric acid catalyst. The oxidative kinetic resolution was applicable to racemic alkyl- or aryl-substituted indolines, and the remaining indolines were obtained in good yields with excellent enantioselectivities.

引用

页码：11740 / 11743

页数：4

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