An Overview of Hepatitis B Virus Surface Antigen Secretion Inhibitors

被引：28
作者：
Mohebbi, Alireza [1 ,2 ]
Lorestani, Nazanin [1 ]
Tahamtan, Alireza [2 ]
Kargar, Niki L. [1 ]
Tabarraei, Alijan [2 ,3 ]
机构：
[1] Golestan Univ Med Sci, Sch Med, Student Res Comm, Gorgan, Iran
[2] Golestan Univ Med Sci, Sch Med, Dept Microbiol, Gorgan, Iran
[3] Golestan Univ Med Sci, Infect Dis Res Ctr, Gorgan, Iran
来源：
FRONTIERS IN MICROBIOLOGY | 2018年 / 9卷
关键词：
hepatitis B virus; chronic hepatitis B virus infection; HBsAg inhibitors; anti-viral natural products; RNA interference; REVERSE-TRANSCRIPTASE SEQUENCES; DRUG-RESISTANCE MUTATIONS; SERUM HBV DNA; NF-KAPPA-B; IN-VIVO; NAIVE; REPLICATION; ENTRY; DERIVATIVES; MICE;
D O I：
10.3389/fmicb.2018.00662
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Current anti-hepatitis B virus (HBV) regimen do not meet ideal result due to emerging resistance strains, cytotoxicity, and unfavorable adverse effects. In chronic HBV infection, high rates of sub-viral particles (SVPs) bearing HBV surface antigen (HBsAg) is a major obstacle regarding to raise effective immune responses and subsequently virus clearance. Development of potent HBsAg secretion inhibitors would provide a better insight into HBV immunopathogenesis and therapy. Investigating new non-toxic HBsAg secretion inhibitors targeting either viral or cellular factors could restore the immune response to remove virally infected hepatocytes after inhibiting SVPs. In this study, we overview several classes of HBV inhibitors with focus on their limitations and advantages over anti-HBsAg secretion potential.
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页数：9
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