Selective Depletion and Enrichment of Constituents in "Curcumin" and Other Curcuma longa Preparations

被引:15
|
作者
Friesen, J. Brent [1 ,2 ,3 ]
Liu, Yang [1 ,2 ,5 ]
Chen, Shao-Nong [1 ,2 ]
McAlpine, James B. [1 ,2 ,4 ]
Pauli, Guido F. [1 ,2 ,4 ]
机构
[1] Univ Illinois, Ctr Nat Prod Technol CENAPT, Program Collaborat Res Pharmaceut Sci PCRPS, Coll Pharm, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA
[3] Dominican Univ, Rosary Coll Arts & Sci, Dept Phys Sci, River Forest, IL 60305 USA
[4] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL 60612 USA
[5] US Pharmacopeial Convent Inc, 12601 Twinbrook Pkwy, Rockville, MD 20852 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 03期
关键词
MEDICINAL CHEMISTRY; DESIGNER EXTRACTS; COUNTERCURRENT; BISDEMETHOXYCURCUMIN; TETRAHYDROCURCUMIN; DEMETHOXYCURCUMIN; CHROMATOGRAPHY; PURIFICATION; BOTANICALS; PHENOLICS;
D O I
10.1021/acs.jnatprod.9b00020
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Much uncertainty exists in science and herbal products referencing turmeric (T), turmeric extract (TE), curcuminoid-enriched turmeric extract (CTE), further processed curcuminoid-enriched materials (CEM), or curcumin as a single-chemical entity. To facilitate the rational chemical and biological assessment of turmeric-derived NPs, we introduced the DESIGNER approach of Depleting and Enriching Select Ingredients to Generate Normalized Extract Resources to Curcuma longa preparations. Countercurrent separation of a commercial CTE yielded four key materials lipophilic metabolites; purified curcumin ("purcumin"); a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin ("purcuminoids"); and hydrophilic metabolites and enabled production of a curcuminoid-free TE ("nocumin"). Their characterization utilized TLC, H-1 (q)NMR spectroscopy, and HPLC.
引用
收藏
页码:621 / 630
页数:10
相关论文
共 50 条
  • [31] Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
    Roney, Miah
    Huq, A. K. M. Moyeenul
    Rullah, Kamal
    Zamri, Normaiza Binti
    Aluwi, Mohd Fadhlizil Fasihi Mohd
    CELL BIOCHEMISTRY AND BIOPHYSICS, 2025, 83 (01) : 53 - 71
  • [32] Antiparasitic efficacy of curcumin from Curcuma longa against Ichthyophthirius multifiliis in grass carp
    Liu, Yan-Meng
    Zhang, Qi-Zhong
    Xu, De-Hai
    Fu, Yao-Wu
    Lin, De-Jie
    Zhou, Sheng-Yu
    Li, Jian-Pei
    VETERINARY PARASITOLOGY, 2017, 236 : 128 - 136
  • [33] Effects of turmeric (Curcuma longa) and its constituent (curcumin) on the metabolic syndrome: An updated review
    Vafaeipour, Zeinab
    Razavi, Bibi Marjan
    Hosseinzadeh, Hossein
    JOURNAL OF INTEGRATIVE MEDICINE-JIM, 2022, 20 (03): : 193 - 203
  • [34] TEMPERATURE AND LIGHT EFFECTS ON TURMERIC (CURCUMA-LONGA L) OLEORESIN EXTRACTS AND CURCUMIN
    MARTINS, MC
    RUSIG, O
    SHIROSE, I
    ARQUIVOS DE BIOLOGIA E TECNOLOGIA, 1994, 37 (04): : 723 - 735
  • [35] QUANTITATIVE ANALYSIS OF CURCUMIN AND RELATED COMPOUNDS IN CURCUMA LONGA BY HPLC AND LC-MS
    Lee, Kwang-Jin
    Pomeroy, Kathie
    Pramanick, Swapan
    Borris, Robert P.
    PHARMACEUTICAL BIOLOGY, 2012, 50 (05) : 591 - 591
  • [36] Triple role of sodium salicylate in solubilization, extraction, and stabilization of curcumin from Curcuma longa
    Degot, Pierre
    Huber, Verena
    El Maangar, Asmae
    Gramueller, Johannes
    Rohr, Lea
    Touraud, Didier
    Zemb, Thomas
    Gschwind, Ruth M.
    Kunz, Werner
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 329
  • [37] Salinity alters curcumin, essential oil and chlorophyll of turmeric (Curcuma longa L.)
    Mostajeran, A.
    Gholaminejad, A.
    Asghari, G.
    RESEARCH IN PHARMACEUTICAL SCIENCES, 2014, 9 (01) : 49 - 57
  • [38] Genotype by environment interaction effects on yield and curcumin in turmeric (Curcuma longa L.)
    Anandaraj, M.
    Prasath, D.
    Kandiannan, K.
    Zachariah, T. John
    Srinivasan, V.
    Jha, A. K.
    Singh, B. K.
    Singh, A. K.
    Pandey, V. P.
    Singh, S. P.
    Shoba, N.
    Jana, J. C.
    Kumar, K. Ravindra
    Maheswari, K. Uma
    INDUSTRIAL CROPS AND PRODUCTS, 2014, 53 : 358 - 364
  • [39] Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review
    Soleimani, Vahid
    Sahebkar, Amirhossein
    Hosseinzadeh, Hossein
    PHYTOTHERAPY RESEARCH, 2018, 32 (06) : 985 - 995
  • [40] Effects of turmeric(Curcuma longa) and its constituent(curcumin) on the metabolic syndrome:An updated review
    Zeinab Vafaeipour
    Bibi Marjan Razavi
    Hossein Hosseinzadeh
    Journal of Integrative Medicine, 2022, 20 (03) : 193 - 203