Selective Depletion and Enrichment of Constituents in "Curcumin" and Other Curcuma longa Preparations

被引：15

作者：

Friesen, J. Brent ^{[1
,2
,3
]}

Liu, Yang ^{[1
,2
,5
]}

Chen, Shao-Nong ^{[1
,2
]}

McAlpine, James B. ^{[1
,2
,4
]}

Pauli, Guido F. ^{[1
,2
,4
]}

机构：

[1] Univ Illinois, Ctr Nat Prod Technol CENAPT, Program Collaborat Res Pharmaceut Sci PCRPS, Coll Pharm, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA

[3] Dominican Univ, Rosary Coll Arts & Sci, Dept Phys Sci, River Forest, IL 60305 USA

[4] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL 60612 USA

[5] US Pharmacopeial Convent Inc, 12601 Twinbrook Pkwy, Rockville, MD 20852 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 03期

关键词：

MEDICINAL CHEMISTRY; DESIGNER EXTRACTS; COUNTERCURRENT; BISDEMETHOXYCURCUMIN; TETRAHYDROCURCUMIN; DEMETHOXYCURCUMIN; CHROMATOGRAPHY; PURIFICATION; BOTANICALS; PHENOLICS;

D O I：

10.1021/acs.jnatprod.9b00020

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Much uncertainty exists in science and herbal products referencing turmeric (T), turmeric extract (TE), curcuminoid-enriched turmeric extract (CTE), further processed curcuminoid-enriched materials (CEM), or curcumin as a single-chemical entity. To facilitate the rational chemical and biological assessment of turmeric-derived NPs, we introduced the DESIGNER approach of Depleting and Enriching Select Ingredients to Generate Normalized Extract Resources to Curcuma longa preparations. Countercurrent separation of a commercial CTE yielded four key materials lipophilic metabolites; purified curcumin ("purcumin"); a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin ("purcuminoids"); and hydrophilic metabolites and enabled production of a curcuminoid-free TE ("nocumin"). Their characterization utilized TLC, H-1 (q)NMR spectroscopy, and HPLC.

引用

页码：621 / 630

页数：10