Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene

被引：2

作者：

Kobayashi, Ichiro ^{[1
]}

Yamazaki, Yasuhiro ^{[1
]}

Tozawa, Yusuke ^{[1
]}

Ueki, Masahiro ^{[1
]}

Takezaki, Shunichiro ^{[1
]}

Yamada, Masafumi ^{[1
]}

Ariga, Tadashi ^{[1
]}

机构：

[1] Hokkaido Univ, Dept Pediat, Grad Sch Med, Sapporo, Hokkaido, Japan

来源：

MODERN RHEUMATOLOGY | 2018年 / 28卷 / 02期

关键词：

Colchicine; Juvenile idiopathic arthritis; Matrix metalloproteinase-3; Methotrexate; Palindromic rheumatism; FAMILIAL MEDITERRANEAN FEVER; FOLLOW-UP; ANTIBODIES; MUTATIONS; SPECTRUM;

D O I：

10.3109/14397595.2015.1106639

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Palindromic rheumatism (PR), a rare disease in children, is characterized by recurrent arthritis or periarthritis and asymptomatic interval. We report evolution of PR to juvenile idiopathic arthritis in a Japanese girl with heterozygous complex L110P-E148Q allele of MEFV gene. Poor response to colchicine alone suggests that the MEFV substitution could increase the susceptibility to arthritis rather than caused arthritis associated with atypical Familial Mediterranean Fever. Weekly methotrexate is a choice for such cases.

引用

页码：365 / 368

页数：4