Association between serum 25-hydroxyvitamin D concentration and severity of first-diagnosed bullous pemphigoid in older adults

被引:1
作者
Sarre, M. E. [1 ,2 ]
Riou, J. [2 ,3 ]
Duval, G. T. [2 ,4 ]
Martin, L. [1 ,2 ]
Annweiler, C. [2 ,4 ,5 ]
机构
[1] Angers Univ Hosp, Dept Dermatol, Angers, France
[2] Sch Med, Angers, France
[3] IBS CHU, Micro & Nanomed Biomimet, INSERM U1066, 4 Rue Larrey, F-49933 Angers, France
[4] Univ Angers, Univ Memory Clin Angers, Angers Univ Hosp,UNAM, Dept Geriatr Med,Res Ctr Auton & Longev,UPRES EA, Angers, France
[5] Univ Western Ontario, Schulich Sch Med & Dent, Robarts Res Inst, Dept Med Biophys, London, ON, Canada
关键词
Vitamin D; Bullous pemphigoid; Severity; Older adults; CRITERIA;
D O I
10.1016/j.archger.2019.03.015
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Higher vitamin D status has been associated with symptom improvement and decreased risk of various autoimmune disorders. Our objective was to determine whether higher serum 25-hydroxyvitamin D (25OHD) concentration correlated with less severe first-diagnosed bullous pemphigoid (BP) in older inpatients. Methods: This cross-sectional study was performed from November 2012 to February 2014 among 30 consecutive older inpatients (21 women; mean +/- SD, 83 +/- 7 years; all Caucasian) with a de novo diagnosis of active BP recruited in the Department of Dermatology of Angers University Hospital, France. The severity of BP was graded clinically on the basis of i) the number of bullae during the first three days of hospitalization (grade 0-4, worse), and ii) the extent of the lesions (grade 0-5, worse). Results: Sixteen participants had <= 5 bullae at the time of diagnosis, 8 had 6-20 bullae, 3 had 20-50 bullae, and 3 had > 50 bullae. The lesions were spread over 5 cutaneous areas in 5 participants (17%). The median 25OHD concentration was 23 [IQR, 16-42] nmol/L. Serum 250HD concentration was inversely correlated with the bullae grade (p = - 0.38, p = 0.04) and the lesion extension grade (p = - 0.50, p = 0.005). Conclusions: Higher serum 25OHD concentration correlated with less severe BP prior to initiation of treatment among our sample of older inpatients. This result suggests that vitamin D may be involved in the pathophysiology of BP and could serve as prognostic biomarker of BP.
引用
收藏
页码:28 / 30
页数:3
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