Nanopore Technology for Biomedical Applications

被引：144

作者：

Desai, Tejal A. ^{[1
]}

Hansford, Derek J. ^{[2
]}

Kulinsky, Lawrence ^{[3
]}

Nashat, Amir H. ^{[4
]}

Rasi, Guido ^{[5
]}

Tu, Jay ^{[6
]}

Wang, Yuchun ^{[7
]}

Zhang, Miqin ^{[8
]}

Ferrari, Mauro ^{[9
]}

机构：

[1] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA

[2] Ohio State Univ, Ctr Biomed Engn, Dept Mat Sci & Engn, Columbus, OH 43210 USA

[3] Univ Calif Berkeley, Dept Mat Sci & Mineral Engn, Berkeley, CA 94720 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[5] CNR, Ist Med Sperimentale, I-00137 Rome, Italy

[6] Alien Technol, Hayward, CA 94545 USA

[7] Appl Mat Inc, Chem Mech Polishing Div, Santa Clara, CA 95054 USA

[8] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA

[9] Ohio State Univ, Ctr Biomed Engn, Columbus, OH 43210 USA

来源：

BIOMEDICAL MICRODEVICES | 1999年 / 2卷 / 01期

基金：

美国国家科学基金会;

关键词：

BioMEMS; nanotechnology; microfabrication; membranes; silicon;

D O I：

10.1023/A:1009903215959

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The ability to create well-defined and controlled interfaces has been an area of great interest over the last few years, particularly in the biomedical arena. This paper will describe the development of technology for the fabrication of nanopore membranes, and their operation in biological environments. With monodisperse pores sizes as small as 10 nanometers, these membranes offer advantages in their reproducibility, and their ability to be integrated with controlled biochemical surface modification protocols. A comprehensive review of results in the areas of nanopore and biocapsule microfabrication technologies, biocompatibility of nanomembrane materials, biologically appropriate post-processing protocols (bonding, sterilization), surface modification protocols, and appropriate mass transport models will be presented. The results point to the potential of using such technologies for therapeutic applications including immunoisolation biocapsules, drug delivery devices, and targeted biorecognition platforms.

引用

页码：11 / 40

页数：30

共 118 条

[1] Threading dynamics of a polymer through parallel pores: Potential applications to DNA size separation [J].