Leukemia inhibitory factor (LIF) mRNA-expressing neuronal subpopulations in adult rat basal forebrain

被引：22
|
作者：
Lemke, R
Gadient, RA
Patterson, PH
Bigl, V
Schliebs, R
机构：
[1] UNIV LEIPZIG,FAC MED,PAUL FLECHSIG INST BRAIN RES,D-04109 LEIPZIG,GERMANY
[2] CALTECH,DIV BIOL,PASADENA,CA 91125
来源：
NEUROSCIENCE LETTERS | 1997年 / 229卷 / 01期
基金：
美国国家卫生研究院;
关键词：
cholinergic differentiation factor; glial fibrillary acidic protein; choline acetyltransferase; parvalbumin; calretinin;
D O I：
10.1016/S0304-3940(97)00421-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have previously found leukemia inhibitory factor (LIF) mRNA in neurons of the adult rat brain. To identify which neuronal subpopulations are expressing LIF transcripts, non-radioactive in situ hybridization was combined with immunocytochemistry for various neuronal markers. Studying the rat basal forebrain and cerebral cortex, we find LIF mRNA is expressed in both cholinergic and GABAergic neurons. These data suggest a role for LIF in the function of these mature neurons. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：69 / 71
页数：3
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