Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in a Greek population of blood donors

被引:0
作者
Antoniadi, T
Hatzis, T
Kroupis, C
Economou-Petersen, E
Petersen, MB
机构
[1] Mitera Matern & Surg Ctr SA, Dept Genet & Mol Biol, GR-15123 Marousi, Greece
[2] Mitera Matern & Surg Ctr SA, Dept Hematol, GR-15123 Marousi, Greece
[3] Drakopoulio Blood Bank Ctr, Athens, Greece
关键词
thrombophilia; factor V; prothrombin; methylenetetrahydrofolate reductase;
D O I
10.1002/(SICI)1096-8652(199908)61:4<265::AID-AJH8>3.3.CO;2-R
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The pathogenesis of venous thrombosis involves the interaction of genetic and environmental factors. In order to estimate the frequency of the factor V Leiden, the prothrombin G20210A, and the MTHFR C677T mutations in the Greek population, we analyzed 160 healthy Greek blood donors by PCR amplification and detected allele frequencies of 2.5%, 2.2%, and 35.3%, respectively. The allele frequencies were compared with reported frequencies of other populations of southern Europe. The identification of these common genetic risk factors for thrombosis should enable easy DNA diagnosis and carrier detection in a high proportion of cases and will contribute to a better understanding of the interaction of genetic and environmental risk factors. (C) 1999 Wiley-Liss, Inc.
引用
收藏
页码:265 / 267
页数:3
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