An Analysis of the Sequence Variability of Meningococcal fHbp, NadA and NHBA over a 50-Year Period in the Netherlands

被引：44

作者：

Bambini, Stefania ^{[1
]}

Piet, Jurgen ^{[2
]}

Muzzi, Alessandro ^{[1
]}

Keijzers, Wendy ^{[2
,3
]}

Comandi, Sara ^{[1
]}

De Tora, Lisa ^{[1
]}

Pizza, Mariagrazia ^{[1
]}

Rappuoli, Rino ^{[1
]}

van de Beek, Diederik ^{[4
]}

van der Ende, Arie ^{[2
,3
]}

Comanducci, Maurizio ^{[1
]}

机构：

[1] Novartis Vaccines & Diagnost, Siena, Italy

[2] Acad Med Ctr, Dept Med Microbiol, Amsterdam, Netherlands

[3] Netherlands Reference Lab Bacterial Meningitis, Amsterdam, Netherlands

[4] Acad Med Ctr, Dept Neurol, Amsterdam, Netherlands

来源：

PLOS ONE | 2013年 / 8卷 / 05期

关键词：

H-BINDING-PROTEIN; NEISSERIA-MENINGITIDIS; VACCINE CANDIDATE; SEROGROUP; DIVERSITY; STRAIN; POPULATIONS; EVOLUTION; DISEASE; SERUM;

D O I：

10.1371/journal.pone.0065043

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies of meningococcal evolution and genetic population structure, including the long-term stability of non-random associations between variants of surface proteins, are essential for vaccine development. We analyzed the sequence variability of factor H-binding protein (fHbp), Neisserial Heparin-Binding Antigen (NHBA) and Neisseria adhesin A (NadA), three major antigens in the multicomponent meningococcal serogroup B vaccine 4CMenB. A panel of invasive isolates collected in the Netherlands over a period of 50 years was used. To our knowledge, this strain collection covers the longest time period of any collection available worldwide. Long-term persistence of several antigen sub/variants and of non-overlapping antigen sub/variant combinations was observed. Our data suggest that certain antigen sub/variants including those used in 4CMenB are conserved over time and promoted by selection.

引用

页数：10

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