An Analysis of the Sequence Variability of Meningococcal fHbp, NadA and NHBA over a 50-Year Period in the Netherlands

被引：44
作者：
Bambini, Stefania [1 ]
Piet, Jurgen [2 ]
Muzzi, Alessandro [1 ]
Keijzers, Wendy [2 ,3 ]
Comandi, Sara [1 ]
De Tora, Lisa [1 ]
Pizza, Mariagrazia [1 ]
Rappuoli, Rino [1 ]
van de Beek, Diederik [4 ]
van der Ende, Arie [2 ,3 ]
Comanducci, Maurizio [1 ]
机构：
[1] Novartis Vaccines & Diagnost, Siena, Italy
[2] Acad Med Ctr, Dept Med Microbiol, Amsterdam, Netherlands
[3] Netherlands Reference Lab Bacterial Meningitis, Amsterdam, Netherlands
[4] Acad Med Ctr, Dept Neurol, Amsterdam, Netherlands
来源：
PLOS ONE | 2013年 / 8卷 / 05期
关键词：
H-BINDING-PROTEIN; NEISSERIA-MENINGITIDIS; VACCINE CANDIDATE; SEROGROUP; DIVERSITY; STRAIN; POPULATIONS; EVOLUTION; DISEASE; SERUM;
D O I：
10.1371/journal.pone.0065043
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Studies of meningococcal evolution and genetic population structure, including the long-term stability of non-random associations between variants of surface proteins, are essential for vaccine development. We analyzed the sequence variability of factor H-binding protein (fHbp), Neisserial Heparin-Binding Antigen (NHBA) and Neisseria adhesin A (NadA), three major antigens in the multicomponent meningococcal serogroup B vaccine 4CMenB. A panel of invasive isolates collected in the Netherlands over a period of 50 years was used. To our knowledge, this strain collection covers the longest time period of any collection available worldwide. Long-term persistence of several antigen sub/variants and of non-overlapping antigen sub/variant combinations was observed. Our data suggest that certain antigen sub/variants including those used in 4CMenB are conserved over time and promoted by selection.
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页数：10
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