Detection of antibodies against hepatitis A in blood spots dried on filter paper. Is this a reliable method for epidemiological studies?

被引：26

作者：

Gil, A

Gonzalez, A

DalRe, R

Dominguez, V

Astasio, P

Aguilar, L

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED,MADRID 28034,SPAIN

[2] UNIV COMPLUTENSE MADRID,SCH MED,PREVENT MED & PUBL HLTH DEPT,E-28040 MADRID,SPAIN

来源：

EPIDEMIOLOGY AND INFECTION | 1997年 / 118卷 / 02期

关键词：

D O I：

10.1017/S0950268896007297

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Diluted dried blood drops on filter paper were compared with serum samples as a specimen source for qualitative anti-HAV antibody determination by ELISA. A total of 298 serum samples and dried blood drops were collected from a population of healthy adolescents (153 +/- 1.2 years old). The prevalence of anti-HAV antibody obtained by testing serum samples was 7.7 % (95 % CI: 4.8-10.1). Compared with serum sampling the sensitivity and specificity of diluted dried blood drops were 91.3 and 99.3 %. The positive and negative predictive values were 91.3 and 99.3 %, respectively, and the likelihood ratios of positive and negative results were 91 and 0.09. It is proposed that this test represents a reliable procedure for anti-HAV antibody testing.

引用

页码：189 / 191

页数：3

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