共 25 条
Endoscopic retrograde cholangiopancreatography in elderly patients: Difficult cannulation and adverse events
被引:16
作者:
Tabak, Fatema
[1
,2
]
Wang, Hui-Shan
[1
,2
]
Li, Quan-Peng
[1
,2
]
Ge, Xian-Xiu
[1
,2
]
Wang, Fei
[1
,2
]
Ji, Guo-Zhong
[1
,2
]
Miao, Lin
[1
,2
]
机构:
[1] Nanjing Med Univ, Affiliated Hosp 2, Inst Digest Endoscopy, 121 Jiangjiayuan Rd, Nanjing 210011, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 2, Med Ctr Digest Dis, 121 Jiangjiayuan Rd, Nanjing 210011, Jiangsu, Peoples R China
关键词:
Endoscopic retrograde cholangiopancreatography;
Difficult cannulation;
Cannulation techniques;
Elderly;
Adverse events;
Post;
endoscopic retrograde cholangiopancreatography pancreatitis;
POST-ERCP PANCREATITIS;
RISK-FACTORS;
SPHINCTEROTOMY;
COMPLICATIONS;
EFFICACY;
DISEASES;
SAFETY;
OLDER;
AGE;
D O I:
10.12998/wjcc.v8.i14.2988
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
BACKGROUND Endoscopic retrograde cholangiopancreatography (ERCP) is a valuable therapeutic technique for pancreatobiliary diseases, and its application in the elderly is no longer limited. However, a higher incidence of procedure difficulty and periprocedural adverse events might be expected in elderly patients due to the presence of other medical disorders and the poor general condition of this population. AIM To evaluate the incidence, causes, and management of difficult biliary cannulation during ERCP in elderly patients and the role of difficult cannulation as a risk factor for adverse events. METHODS A total of 614 patients who underwent ERCP during the study period were prospectively studied and divided into two groups based on their age. One hundred and forty-six patients were aged 80 years or older and 468 patients were aged less than 80 years. The primary outcome measurements were cannulation difficulty, cannulation success rate, ERCP procedure time, and related adverse events. RESULTS There was no difference in the incidence of difficult cannulation among the two groups (32.9%vs34.4%,P= 0.765), as well as in the cannulation success rate (96.6%vs96.8%,P= 0.54). The cannulation techniques were shown to be safe and efficient in achieving successful cannulation. Logistic regression analysis showed that patients aged 80 years or older were not associated with increased adverse events; however, difficult cannulation cases [adjusted odds ratio (AOR) = 3.478; 95% confidence interval (CI): 1.877-6.442;P< 0.001] and patients with Charlson Comorbidity Index >= 2 (AOR = 1.824; 95%CI: 0.993-3.349;P= 0.045) were more likely to develop adverse events. In contrast, other factors including age <= 65 (AOR = 3.460; 95%CI: 1.511-7.922;P= 0.003), female gender (AOR = 2.362; 95%CI=1.089-5.124;P= 0.030), difficult cannulation (AOR = 4.527; 95%CI: 2.078-9.860;P< 0.001), and patients with cholangitis (AOR = 3.261; 95%CI: 1.204-8.832;P= 0.020) were strongly associated with a higher rate of post-ERCP pancreatitis. CONCLUSION Advanced age has not been proved to be a risk factor for difficult cannulation, and secondary cannulation techniques can be safely and efficaciously utilized in this group. Patients with a Charlson Comorbidity Index >= 2 and difficult cannulation are associated with an increased overall adverse events rate, while age >= 80 years is not.
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页码:2988 / 2999
页数:12
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