A polygenic model with common variants may predict lung adenocarcinoma risk in humans

被引：11

作者：

Galvan, Antonella

Falvella, Felicia S.

Spinola, Monica

Frullanti, Elisa ^{[2
]}

Leoni, Vera P.

Noci, Sara

Alonso, Maria R. ^{[3
]}

Zolin, Anna ^{[2
,4
]}

Spada, Elena ^{[4
]}

Milani, Silvano ^{[4
]}

Pastorino, Ugo

Incarbone, Matteo ^{[5
]}

Santambrogio, Luigi ^{[2
]}

Neira, Anna Gonzalez ^{[3
]}

Dragani, Tommaso A. ^{[1
]}

机构：

[1] Ist Nazl Tumori, Fdn IRCCS, Dept Expt Oncol, I-20133 Milan, Italy

[2] Univ Milan, Policlin Mangiagalli & Regina Elena, Osped Maggiore, Fdn IRCCS, Milan, Italy

[3] CNIO, Genotyping Unit CeGen, Madrid, Spain

[4] Univ Milan, Ist Stat Med & Biometria GA Maccacaro, Milan, Italy

[5] Ist Clin Humanitas, Rozzano, Italy

来源：

INTERNATIONAL JOURNAL OF CANCER | 2008年 / 123卷 / 10期

关键词：

lung adenocarcinoma; smoking; genetic susceptibility; single-nucleotide polymorphisms; genome-wide association;

D O I：

10.1002/ijc.23789

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNIP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population. (C) 2008 Wiley-Liss. Inc.

引用

页码：2327 / 2330

页数：4

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