Distribution of H2S Synthesis Enzymes in the Walls of Cerebral Arteries in Rats

被引:13
|
作者
Chertok, V. M. [1 ]
Kotsyuba, A. E. [1 ]
机构
[1] Vladivostok State Med Univ, Dept Human Anat, Vladivostok, Russia
关键词
internal carotid artery; pial and intracerebral arteries; H2S; cystationine beta-synthase; cystationine gamma-liase; HYDROGEN-SULFIDE;
D O I
10.1007/s10517-012-1886-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The distribution of two enzymes involved in H2S synthesis, cystationine beta-synthase (CBS) and cystationine gamma-liase (CSE), was studied in the walls of the internal carotid artery, order I-V branches of the middle cerebral artery basin, and intracerebral vessels of adult Wistar rats. Immunohistochemical staining showed the presence of CBS in the endothelium of small pial arteries (order IV-V branches) and intracerebral arterioles and in the capillary walls, neurons, and vascular nerves. As for CSE, in the internal carotid artery and large (order I-II) pial branches it was found mainly in the tunica media myocytes, in order III-IV vessels in myocytes and endothelium, and in smaller pial and intracerebral vessels in the endothelium. Along with enzyme-positive vessels, many pial and intracerebral arteries contained no these enzymes in the walls.
引用
收藏
页码:104 / 107
页数:4
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