The nature of neonatal status epilepticus - a clinician's perspective

被引:5
作者
Dlugos, Dennis J. [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA
关键词
Neonatal seizures; Status epilepticus; SEIZURES; CLASSIFICATION;
D O I
10.1016/j.yebeh.2015.04.025
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Neonatal status epilepticus occurs within the substrate of the hyperexcitable newborn brain and is usually provoked by acute CNS derangements, although status can also be the presentation of early-life epilepsy. Provoked neonatal status usually resolves within a few days, with or without treatment, but new data suggests that status is associated with adverse outcomes, even after controlling for underlying disease severity and MRI structural brain injury. Novel treatments may be needed to improve seizure control and outcome, given the characteristics of neurotransmission in the newborn brain. (C) 2015 Elsevier Inc. All rights reserved
引用
收藏
页码:88 / 89
页数:2
相关论文
共 11 条
  • [1] Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy
    Abend, Nicholas S.
    Wusthoff, Courtney J.
    Goldberg, Ethan M.
    Dlugos, Dennis J.
    [J]. LANCET NEUROLOGY, 2013, 12 (12) : 1170 - 1179
  • [2] [Anonymous], 1997, WEBSTERS NEW WORLD C
  • [3] Status epilepticus - A clinical and pathological study in epilepsy
    Clark, LP
    Prout, TP
    [J]. AMERICAN JOURNAL OF INSANITY, 1903, 60 (02): : 291 - 306
  • [4] Setting the scene: definition of prolonged seizures, acute repetitive seizures, and status epilepticus. Do we know why seizures stop?
    Cross, J. Helen
    [J]. EPILEPTIC DISORDERS, 2014, 16 : S2 - S5
  • [5] Epigraph ILAE, 2014, STAT EP, V16
  • [6] GASTAUT H, 1964, EPILEPSIA, V5, P297
  • [7] CHARACTERIZATION AND CLASSIFICATION OF NEONATAL SEIZURES
    MIZRAHI, EM
    KELLAWAY, P
    [J]. NEUROLOGY, 1987, 37 (12) : 1837 - 1844
  • [8] Phenobarbital compared with phenytoin for the treatment of neonatal seizures
    Painter, MJ
    Scher, MS
    Stein, AD
    Armatti, S
    Wang, ZM
    Gardiner, JC
    Paneth, N
    Minnigh, B
    Alvin, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (07) : 485 - 489
  • [9] Epileptogenesis in the immature brain: emerging mechanisms
    Rakhade, Sanjay N.
    Jensen, Frances E.
    [J]. NATURE REVIEWS NEUROLOGY, 2009, 5 (07) : 380 - 391
  • [10] The American Clinical Neurophysiology Society's Guideline on Continuous Electroencephalography Monitoring in Neonates
    Shellhaas, Renee A.
    Chang, Taeun
    Tsuchida, Tammy
    Scher, Mark S.
    Riviello, James J.
    Abend, Nicholas S.
    Sylvie Nguyen
    Wusthoff, Courtney J.
    Clancy, Robert R.
    [J]. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2011, 28 (06) : 611 - 617