A Facile and Efficient Solid Supported, One-Pot Synthesis of Functionalized Piperidine Derivatives Catalyzed by Amberlite IRA400-Cl Resin/I2/KI via Multicomponent Reaction

被引：26

作者：

Harichandran, Gurusamy ^{[1
]}

Amalraj, Savarimuthu David ^{[1
]}

Shanmugam, Ponnusamy ^{[2
]}

机构：

[1] Univ Madras, Dept Polymer Sci, Chennai 600025, Tamil Nadu, India

[2] Cent Leather Res Inst, Organ Chem Lab, Chennai 600020, Tamil Nadu, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 03期

关键词：

Piperidine derivatives; Multi-component reaction; Amberlite resin; Solid supported; ECONOMIC PASE SYNTHESIS; DIELS-ALDER REACTION; CYCLIZATION REACTIONS; POWERFUL CATALYST; CONCISE SYNTHESIS; MICHAEL REACTION; IODINE; ATOM; CONSTRUCTION; INHIBITORS;

D O I：

10.1002/jhet.1516

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient one-pot, solid supported synthesis of functionalized piperidine derivatives catalyzed by Amberlite IRA400-Cl resin/I2/KI via a multicomponent reaction of various aldehydes, aromatic amines, and 1,3-dicarbonyl compounds has been achieved. The reaction has been carried out in a one-pot reaction and Amberlite resin as a solid supported catalyst at room temperature. Shorter reaction time, easy workup, yield, and mild reaction condition make the novel synthetic strategy both practical and attractive.

引用

页码：539 / 543

页数：5

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