Invasive Mold Infections After Chimeric Antigen Receptor-Modified T-Cell Therapy: A Case Series, Review of the Literature, and Implications for Prophylaxis

被引：74

作者：

Haider, Ghady ^{[1
,2
]}

Dorritie, Kathleen ^{[1
,3
]}

Farah, Rafic ^{[3
]}

Bogdanovich, Tatiana ^{[2
]}

Nguyen, M. Hong ^{[1
,2
]}

Samanta, Palash ^{[2
]}

机构：

[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

[2] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA USA

[3] Univ Pittsburgh, Med Ctr, Div Hematol & Oncol, Pittsburgh, PA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 03期

关键词：

CAR-T-cell; fungal infections; neutropenia; prophylaxis; steroids; FLUCONAZOLE; EPIDEMIOLOGY; POSACONAZOLE; RISK;

D O I：

10.1093/cid/ciz1127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Data on invasive mold infections (IMIs) after chimeric antigen receptor-modified T-cell (CAR-T-cell) therapy are limited. We describe 2 patients with post-CAR-T-cell IMI (Fusarium, Mucorales) and review the published literature. We propose strategies to prevent IMIs in patients, based on the IMI rate and presence of neutropenia or steroid use.

引用

页码：672 / 676

页数：5

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