A new mechanistic model for gas liquid two-phase flow with mass transfer through the pipe wall, which account's for the effects of wall inflow or outflow oil wall friction, acceleration and flow pattern transition, has been developed. Four individual flow patterns, including stratified flow, annular-mist flow, bubble flow and intermittent flow, are considered in the mechanistic model. Models for individual flow patterns have been developed. Transition mechanisms among different flow patterns are discussed and new transition criteria are proposed. Predictions by the new mechanistic model are compared with experimental data obtained oil a large industrial facility.