Antibiotic peptides from higher eukaryotes: biology and applications

被引：171

作者：

Ganz, T ^{[1
]}

Lehrer, RI

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Will Rogers Inst Pulm Res, Los Angeles, CA 90095 USA

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 07期

关键词：

D O I：

10.1016/S1357-4310(99)01490-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene-encoded antibiotic peptides are increasingly being recognized as effector molecules of host defense in plants and animals. Studies of antimicrobial peptides are providing new insights into the dynamic interactions between microbes and their hosts, and are generating new paradigms for the pathogenesis and treatment of diseases. Because antimicrobial peptides of higher eukaryotes differ structurally from conventional antibiotics produced by bacteria and fungi, they offer novel templates for pharmaceutical compounds that could be effective against increasingly resistant microbes.

引用

页码：292 / 297

页数：6

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