Structural alterations of fully hydrated human stratum corneum

被引：26
作者：
Charalambopoulou, G. Ch. [1 ]
Steriotis, Th. A. [1 ]
Hauss, Th. [2 ]
Stubos, A. K. [1 ]
Kanellopoulos, N. K. [1 ]
机构：
[1] Natl Ctr Sci Res Demokritos, Athens 15310, Greece
[2] BENSC, Hahn Meitner Inst, D-14109 Berlin, Germany
来源：
PHYSICA B-CONDENSED MATTER | 2004年 / 350卷 / 1-3期
关键词：
Stratum corneum; Hydration; Lamellar structure; Neutron diffraction;
D O I：
10.1016/j.physb.2004.03.161
中图分类号：
O469 [凝聚态物理学];
学科分类号：
070205 ;
摘要：
The diffusional barrier function of skin is associated with the superficial epidermal layer, the stratum corneum, a highly complex biomembrane consisting of a staggered corneocyte arrangement in a lipid lamellar continuum. One of the key elements for stratum corneum barrier function is its hydration state. In the present work, the membrane neutron diffraction method is employed to reveal important stratum corneum structural changes that emanate upon water uptake. Increasing stratum corneum water content was observed to lead reversibly to the progressive disruption of the highly ordered lipid configuration and the distortion of the system's barrier function. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：E603 / E606
页数：4
相关论文
共 9 条
  • [1] EFFECT OF HYDRATION UPON THE FLUIDITY OF INTERCELLULAR MEMBRANES OF STRATUM-CORNEUM - AN EPR STUDY
    ALONSO, A
    MEIRELLES, NC
    TABAK, M
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1237 (01): : 6 - 15
  • [2] STRUCTURE OF HUMAN STRATUM-CORNEUM AS A FUNCTION OF TEMPERATURE AND HYDRATION - A WIDE-ANGLE X-RAY-DIFFRACTION STUDY
    BOUWSTRA, JA
    GOORIS, GS
    SALOMONSDEVRIES, MA
    VANDERSPEK, JA
    BRAS, W
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1992, 84 (03) : 205 - 216
  • [3] BOUWSTRA JA, 1995, J LIPID RES, V36, P685
  • [4] A neutron-diffraction study of the effect of hydration on stratum corneum structure
    Charalambopoulou, GC
    Steriotis, TA
    Hauss, T
    Stefanopoulos, KL
    Stubos, AK
    [J]. APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2002, 74 (Suppl 1): : S1245 - S1247
  • [5] Investigation of lipid organization on stratum corneum by water absorption in conjunction with neutron scattering
    Charalambopulou, GC
    Steriotis, TA
    Stefanopoulos, KL
    Mitropoulos, AC
    Kanellopoulos, NK
    Keiderling, U
    [J]. PHYSICA B, 2000, 276 : 530 - 531
  • [6] ELIAS PM, 1983, J INVEST DERMATOL, V80, pS44, DOI 10.1038/jid.1983.12
  • [7] DOES HYDRATION AFFECT INTERCELLULAR LIPID ORGANIZATION IN THE STRATUM-CORNEUM
    MAK, VHW
    POTTS, RO
    GUY, RH
    [J]. PHARMACEUTICAL RESEARCH, 1991, 8 (08) : 1064 - 1065
  • [8] Structure of fully hydrated human stratum corneum: A freeze fracture electron microscopy study
    vanHal, DA
    Jeremiasse, E
    Junginger, HE
    Spies, F
    Bouwstra, JA
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (01) : 89 - 95
  • [9] Hydration disrupts human stratum corneum ultrastructure
    Warner, RR
    Stone, KJ
    Boissy, YL
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (02) : 275 - 284
1