Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study

被引:28
作者
Kim, Tae Ho [1 ,2 ]
Carroll, Judith E. [3 ]
An, Suk Kyoon [1 ,2 ]
Seeman, Teresa E. [4 ]
Namkoong, Kee [1 ,2 ]
Lee, Eun [1 ,2 ]
机构
[1] Yonsei Univ, Coll Med, Inst Behav Sci Med, Seoul, South Korea
[2] Yonsei Univ, Coll Med, Dept Psychiat, Yonsei Ro 50, Seoul 03722, South Korea
[3] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Geriatr, Los Angeles, CA 90095 USA
基金
新加坡国家研究基金会;
关键词
Sleep onset latency; Insulin resistance; Inflammation; Actigraphy; Women; HOMEOSTASIS MODEL ASSESSMENT; SELF-REPORTED SLEEP; GLUCOSE-METABOLISM; SEX-DIFFERENCES; DURATION; ADULTS; HEART; RISK; COAGULATION; DISTURBANCE;
D O I
10.1016/j.sleep.2016.07.023
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Disturbed sleep has been associated with increased insulin resistance and elevated inflammation. Although there is growing body of evidence that activation of inflammatory pathways plays a crucial role in the development of insulin resistance, the mediational model whereby sleep disturbances influence inflammation that drives insulin resistance has not been fully assessed in general population studies with objectively measured sleep. This study aimed to examine associations between objectively measured sleep, inflammatory markers, and insulin resistance simultaneously and in a mediational analysis, thereby offering insights into the possible causal model. Methods: Cross-sectional data collected from 2004 to 2009 during the Midlife Development in the United States II biomarker project were used. The study population included 374 community-based participants (138 men and 236 women) who completed seven nights of wrist actigraphy. Multiple regressions controlling for age and statistically significant variables in univariate regressions were performed to evaluate the associations between actigraphy-assessed sleep measures, inflammatory cytokines, and insulin resistance. Results: The regression models showed that in women, higher sleep onset latency (SOL) was associated with higher insulin resistance after controlling for age, smoking, obesity, diabetes, depression, and inflammatory cytokines. Higher SOL was also associated with higher interleukin (IL)-6 and C-reactive protein (CRP) levels in women, but no association was found in men. Using mediation models in women, the association between SOL and insulin resistance was partially explained by the indirect effect of inflammatory cytokines. Conclusion: A combination of inflammation and other unidentified pathways may contribute to the relationship between disturbed sleep and glucose homeostasis. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:72 / 79
页数:8
相关论文
共 41 条
[1]   Blunted heart rate dip during sleep and all-cause mortality [J].
Ben-Dov, Iddo Z. ;
Kark, Jeremy D. ;
Ben-Ishay, Drori ;
Mekler, Judith ;
Ben-Arie, Liora ;
Bursztyn, Michael .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (19) :2116-2121
[2]   The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms [J].
Briancon-Marjollet, Anne ;
Weiszenstein, Martin ;
Henri, Marion ;
Thomas, Amandine ;
Godin-Ribuot, Diane ;
Polak, Jan .
DIABETOLOGY & METABOLIC SYNDROME, 2015, 7
[3]   Inflammation, insulin resistance, and diabetes-mendelian randomization using CRP haplotypes points upstream [J].
Brunner, Eric J. ;
Kivimaeki, Mika ;
Witte, Daniel R. ;
Lawlor, Debbie A. ;
Smith, George Davey ;
Cooper, Jackie A. ;
Miller, Michelle ;
Lowe, Gordon D. O. ;
Rumley, Ann ;
Casas, Juan P. ;
Shah, Tina ;
Humphries, Steve E. ;
Hingorani, Aroon D. ;
Marmot, Michael G. ;
Timpson, Nicholas J. ;
Kumari, Meena .
PLOS MEDICINE, 2008, 5 (08) :1278-1286
[4]  
Buysse D J, 1989, Psychiatry Res, V28, P193
[5]   Gender-specific associations of short sleep duration with prevalent and incident hypertension - The Whitehall II study [J].
Cappuccio, Francesco P. ;
Stranges, Saverio ;
Kandala, Ngianga-Bakwin ;
Miller, Michelle A. ;
Taggart, Frances M. ;
Kumari, Meena ;
Ferrie, Jane E. ;
Shipley, Martin J. ;
Brunner, Eric J. ;
Marmot, Michael G. .
HYPERTENSION, 2007, 50 (04) :693-700
[6]   Quantity and Quality of Sleep and Incidence of Type 2 Diabetes - A systematic review and meta-analysis [J].
Cappuccio, Francesco P. ;
D'Elia, Lanfranco ;
Strazzlillo, Pasquale ;
Miller, Michelle A. .
DIABETES CARE, 2010, 33 (02) :414-420
[7]   Changes in Insulin Secretion and Action in Adults With Familial Risk for Type 2 Diabetes Who Curtail Their Sleep [J].
Darukhanavala, Amy ;
Booth, John N., III ;
Bromley, Lindsay ;
Whitmore, Harry ;
Imperial, Jacqueline ;
Penev, Plamen D. .
DIABETES CARE, 2011, 34 (10) :2259-2264
[8]   Sleep onset and cardiovascular activity in primary insomnia [J].
de Zambotti, Massimiliano ;
Covassin, Naima ;
Tona, Giuliano de Min ;
Sarlo, Michela ;
Stegagno, Luciano .
JOURNAL OF SLEEP RESEARCH, 2011, 20 (02) :318-325
[9]   Metabolic Consequences of Sleep and Circadian Disorders [J].
Depner, Christopher M. ;
Stothard, Ellen R. ;
Wright, Kenneth P., Jr. .
CURRENT DIABETES REPORTS, 2014, 14 (07)
[10]   Validation of Self-Reported Sleep Against Actigraphy [J].
Girschik, Jennifer ;
Fritschi, Lin ;
Heyworth, Jane ;
Waters, Flavie .
JOURNAL OF EPIDEMIOLOGY, 2012, 22 (05) :462-468