Low pretreatment serum concentration of vitamin D at breast cancer diagnosis in postmenopausal women

被引:11
作者
Matos Machado, Murilo Renato [1 ]
Almeida-Filho, Benedito de Sousa [1 ]
Vespoli, Heloisa De Luca [1 ]
Schmitt, Eneida Boteon [1 ]
Nahas-Neto, Jorge [1 ]
Nahas, Eliana A. P. [1 ]
机构
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2019年 / 26卷 / 03期
关键词
Breast cancer; Menopause; Obesity; Vitamin D; BODY-MASS INDEX; CLINICAL ONCOLOGY/COLLEGE; 1,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D; AMERICAN SOCIETY; HIGH PREVALENCE; D DEFICIENCY; OBESITY; RISK; RECOMMENDATIONS;
D O I
10.1097/GME.0000000000001203
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The aim of the study was to evaluate the rate of and risk factors for low pretreatment vitamin D (VitD) levels in postmenopausal breast cancer (BC) women, compared with postmenopausal women without BC. Methods: A cross-sectional clinical study was conducted to compare 209 women with BC (case group) to 418 women without BC (control group), age range: 45 to 75 years. The case group consisted of women diagnosed with BC, amenorrhea >= 12 months, aged >= 45 years, without use of medication or clinical conditions that might interfere with VitD levels. The control group consisted of women with amenorrhea >= 12 months, aged >= 45 years, without BC. The groups were matched for age and time since menopause, at a case: control ratio of 1:2. Serum 25-hydroxyvitamin-D [25(OH) D] concentration was measured in all women 10 to 20 days after BC diagnosis and before the proposed treatment. Serum levels >= 30 ng/mL were defined as sufficient. The Student's t test or gamma distribution, x(2) test, and logistic regression (odds ratio, OR) were used for statistical analysis. Results: The BC group had a higher body mass index (BMI) and higher percentage of obesity than the control group (57.4% vs 40.2%, P < 0.0001). In addition, rates of insufficient (20-29 ng/mL) and deficient (<20 ng/mL) 25(OH) D levels were higher in BC patients than in controls (55.6% vs 49.3%, P = 0.039 and 26.2% vs 20.3%, P = 0.018), respectively. In risk analysis (adjusted for age, time since menopause, and BMI), BC patients had a 1.5-fold higher risk of developing low VitD levels (OR = 1.52, 95% CI, 1.04-2.22, P = 0.029) than women without BC. Conclusions: Postmenopausal women had an increased risk of VitD deficiency at the time of BC diagnosis, associated with a higher rate of obesity, than women of the same age group without cancer.
引用
收藏
页码:293 / 299
页数:7
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