Professional antigen presenting cells in human herpesvirus 8 infection

被引：18

作者：

Knowlton, Emilee R. ^{[1
]}

Lepone, Lauren M. ^{[1
]}

Li, Jun ^{[1
]}

Rappocciolo, Giovanna ^{[1
]}

Jenkins, Frank J. ^{[1
,2
]}

Rinaldo, Charles R. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, A419 Crabtree Hall,130 DeSoto St, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15261 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 3卷

基金：

美国国家卫生研究院;

关键词：

human herpesvirus 8; Kaposi's sarcoma; multicentric Castleman's disease; primary effusion lymphoma; dendritic cells; monocytes/macrophages; B lymphocytes; CD4 and CD8 T lymphocytes; SARCOMA-ASSOCIATED-HERPESVIRUS; REGULATORY T-CELLS; MULTICENTRIC CASTLEMAN-DISEASE; PRIMARY EFFUSION LYMPHOMA; NF-KAPPA-B; IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; PROTEIN-COUPLED RECEPTOR; SYSTEMIC LYMPHOPROLIFERATIVE DISORDER; CELLULAR IMMUNE-RESPONSES;

D O I：

10.3389/fimmu.2012.00427

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Professional antigen presenting cells (APC), i.e., dendritic cells (DC), monocytes/macrophages, and B lymphocytes, are critically important in the recognition of an invading pathogen and presentation of antigens to the T cell mediated arm of immunity. Human herpesvirus 8 (HHV-8) is one of the few human viruses that primarily targets these APC for infection, altering their cytokine profiles, manipulating their surface expression of MHC molecules, and altering their ability to activate HHV-8-specific T cells. This could be why T cell responses to HHV-8 antigens are not very robust. Of these ARC, only B cells support complete, lytic HHV-8 infection. However, both complete and abortive virus replication cycles in ARC could directly affect viral pathogenesis and progression to Kaposi's sarcoma (KS) and HHV-8-associated B cell cancers. In this review, we discuss the effects of HHV-8 infection on professional ARC and their relationship to the development of KS and B cell lymphomas.

引用

页数：18

共 247 条

[1] Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse components [J].