Preterm premature rupture of the membranes before viability

Preterm premature rupture of the membranes before viability is an uncommon, yet devastating complication of pregnancy. Although the cause is not well understood, the perinatal morbidity and mortality have been carefully documented, including the substantial risk of pulmonary hypoplasia. During the past 5 years, improved outcome has been reported, perhaps because of the use of prenatal corticosteroids, antibiotics, neonatal surfactant, and improved mechanical ventilation. The long-term prognosis of babies born with this complication, however, remains guarded.