Research Progress In Necroptosis

被引：0
|
作者：
Shi Shen-Nan [1 ]
Qin Xia [2 ,3 ]
Wang Hong-Yang [1 ,2 ,3 ]
Cai Zhen-Yu [1 ,2 ,3 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Canc Inst, Dept Oncol,Shanghai Med Coll, Shanghai 200032, Peoples R China
[2] Natl Ctr Liver Canc, Shanghai 201805, Peoples R China
[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2020年 / 47卷 / 07期
基金：
中国国家自然科学基金;
关键词：
programmed cell death; necroptosis; inflammation; RIPK3; MLKL; NF-KAPPA-B; DOMAIN-LIKE PROTEIN; NECROSIS-FACTOR-ALPHA; CELL-DEATH; TUMOR-NECROSIS; PROGNOSTIC BIOMARKER; MEDIATES NECROPTOSIS; PROGRAMMED NECROSIS; RIP KINASES; INFLAMMATION;
D O I：
10.16476/j.pibb.2019.0209
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Programmed cell death is critical for maintenance cellular organisms homeostasis. Necroptosis is a recently identified mode of programmed cell death that morphologically similar to necrosis. Necroptosis is mediated by receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and its substrate mixed lineage kinase domain-like protein(MLKL). It has been shown that necroptosis is related to several human diseases, such as inflammatory diseases, autoimmune diseases, tumors and degenerative diseases. In this review, we will discuss the molecular mechanisms of necroptosis and its associated diseases.
引用
收藏
页码：561 / 573
页数：13
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