Orchestrating Cell/Material Interactions For Tissue Engineering of Surgical Implants

被引：20

作者：

de Mel, Achala ^{[1
,2
]}

Seifalian, Alexander M. ^{[1
,3
]}

Birchall, Martin A. ^{[1
,2
]}

机构：

[1] UCL, Div Surg & Intervent Sci, UCL Ctr Nanotechnol & Regenerat Med, London, England

[2] Royal Natl Throat Nose & Ear Hosp, UCL Ear Inst, London WC1X 8DA, England

[3] Royal Free Hampstead NHS Trust Hosp, London, England

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 08期

基金：

英国医学研究理事会;

关键词：

cells; extracellular matrix; nanocomposites; scaffolds; tissue engineering; IRON-OXIDE NANOPARTICLES; STEM-CELL FATE; QUANTUM DOTS; 3-DIMENSIONAL SCAFFOLDS; CONDUCTING POLYMERS; VASCULARIZATION; BIOMATERIALS; NANOFIBERS; STRATEGIES; NANOCOMPOSITE;

D O I：

10.1002/mabi.201200039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research groups are currently recognising a critical clinical need for innovative approaches to organ failure and agenesis. Allografting, autologous reconstruction and prosthetics are hampered with severe limitations. Pertinently, readily available laboratory-grown organs and implants are becoming a reality. Tissue engineering constructs vary in their design complexity depending on the specific structural and functional demands. Expeditious methods on integrating autologous stem cells onto nanoarchitectured 3D nanocomposites, are being transferred from lab to patients with a number of successful first-in-man experiences. Despite the need for a complete understanding of cell/material interactions tissue engineering is offering a plethora of exciting possibilities in regenerative medicine.

引用

页码：1010 / 1021

页数：12

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