Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma

被引：7

作者：

Yoshida, Naohisa ^{[1
]}

Nomura, Kenichi ^{[1
]}

Matsumoto, Yosuke ^{[1
]}

Nishida, Kazuhiro ^{[1
]}

Wakabayashi, Naoki ^{[1
]}

Konishi, Hideyuki ^{[1
]}

Mitsufuji, Shoji ^{[1
]}

Kataoka, Keisho ^{[1
]}

Okanoue, Takeshi ^{[1
]}

Taniwaki, Masafumi ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kamigyo Ku, Kyoto 6028566, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2004年 / 10卷 / 17期

关键词：

D O I：

10.3748/wjg.v10.i17.2602

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 59-year-old woman was admitted to our hospital because of recurrent follicular lymphoma (FL). Colonoscopic examination revealed a rectal submucosal tumor (SMT) without any erosions and ulcers. In this patient, it was difficult to distinguish non-Hodgkin's lymphoma (NHL) invasion from other disorders of the colon including carcinoid tumor merely based on endoscopic findings. Histopathologic and immunohistochemical studies on biopsy specimens showed an infiltration of atypical lymphocytes that were positive for CD20 and BCL2 but negative for UCHL-1. Fluorescence in situ hybridization on paraffin-embedded tissue sections (T-FISH) identified a translocation of BCL2 with IGH gene. Based on these findings, the tumor was defined as an invasion of FL. T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract, and particularly for the detection of chromosomal translocations specific to lymphoma subtypes.

引用

页码：2602 / 2604

页数：3

共 17 条

[1]

[Anonymous], 2001, Tumours of the Haematopoietic and Lymphoid Tissues

[2]

COULSON WF, 1988, SURG PATHOLOGY, P123

[3]

Crump M, 1999, SEMIN ONCOL, V26, P324

[4] Primary follicular lymphoma of the gastrointestinal tract:: a study of 25 cases and a literature review [J].

Damaj, G ;

Verkarre, V ;

Delmer, A ;

Solal-Celigny, P ;

Yakoub-Agha, L ;

Cellier, C ;

Maurschhauser, F ;

Bouabdallah, R ;

Leblond, V ;

Lefrère, F ;

Bouscary, D ;

Audouin, J ;

Coiffier, B ;

Varet, B ;

Molina, T ;

Brousse, N ;

Hermine, O .

ANNALS OF ONCOLOGY, 2003, 14 (04) :623-629

[5]

FRAZEE RC, 1992, SURG CLIN N AM, V72, P423

[6] Primary gastrointestinal non-Hodgkin's lymphoma in adults: a population-based clinical and histopathologic study [J].

Hansen, PB ;

Vogt, KC ;

Skov, RL ;

Pedersen-Bjergaard, U ;

Jacobsen, M ;

Ralfkiaer, E .

JOURNAL OF INTERNAL MEDICINE, 1998, 244 (01) :71-78

[7] Real-time quantitative RT-PCR of cyclin D1 mRNA in mantle cell lymphoma: Comparison with FISH and immunohistochemistry [J].

Hui, P ;

Howe, JG ;

Crouch, J ;

Nimmakayalu, M ;

Qumsiyeh, MB ;

Tallini, G ;

Flynn, SD ;

Smith, BR .

LEUKEMIA & LYMPHOMA, 2003, 44 (08) :1385-1394

[8] Endoscopic submucosal tumorectomy for gastrointestinal submucosal tumors restricted to the submucosa: a new form of endoscopic minimal surgery [J].

Kawamoto, K ;

Yamada, Y ;

Furukawa, N ;

Utsunomiya, T ;

Haraguchi, Y ;

Mizuguchi, M ;

Oiwa, T ;

Takano, H ;

Masuda, K .

GASTROINTESTINAL ENDOSCOPY, 1997, 46 (04) :311-317

[9] Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization [J].

Nomura, K ;

Yoshino, T ;

Nakamura, S ;

Akano, Y ;

Tagawa, H ;

Nishida, K ;

Seto, M ;

Nakamura, S ;

Ueda, R ;

Yamagishi, H ;

Taniwaki, M .

CANCER GENETICS AND CYTOGENETICS, 2003, 140 (01) :49-54

[10] Differentiation of follicular from mucosa-associated lymphoid tissue lymphoma by detection of t(14;18) on single-cell preparations and paraffin-embedded sections [J].

Nomura, K ;

Sekoguchi, S ;

Ueda, K ;

Nakao, M ;

Akano, Y ;

Fujita, Y ;

Yamashita, Y ;

Horiike, S ;

Nishida, K ;

Nakamura, S ;

Taniwaki, M .

GENES CHROMOSOMES & CANCER, 2002, 33 (02) :213-216

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