Copper(I)-Catalyzed [3+2]Cycloaddition/Ring-Opening Rearrangement/[4+2]Cycloaddition/Aromatization Cascade: An Unprecedented Chemo- and Stereoselective Three Component Coupling of Sulfonyl Azide, Alkyne and N-Arylidenepyridin-2-amine to Pyrido[1,2-a]pyrimidin-4-imine

被引：27

作者：

Namitharan, Kayambu ^{[1
]}

Pitchumani, Kasi ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 01期

关键词：

fused-ring systems; heterogeneous catalysis; multicomponent reactions; stereoselectivity; ONE-POT SYNTHESIS; ONE-STEP SYNTHESIS; 3-COMPONENT REACTION; DRUG DISCOVERY; HY ZEOLITE; MULTICOMPONENT; CATALYST; FRAMEWORKS; INDOLINES; ROUTE;

D O I：

10.1002/adsc.201200654

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel synthetic protocol for the one-pot chemo- and stereoselective construction of diversely functionalized pyrido[1,2-a]pyrimidin-4-imines via copper(I)-catalyzed [3+2]?cycloaddition/ring-opening rearrangement/[4+2]?cycloaddition/aromatization cascade of sulfonyl azides, alkynes and N-arylidenepyridin-2-amines under mild reaction conditions is reported. In addition, the catalytic activity of copper(I)-modified zeolite, a recyclable, heterogeneous catalyst is also investigated, which gives improved yield compared to its homogeneous equivalents.

引用

页码：93 / 98

页数：6

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