telomere;
institutionalization;
early childhood;
gender;
EARLY INTERVENTION PROJECT;
GLUCOCORTICOID-RECEPTOR;
PSYCHIATRIC-DISORDERS;
EPIGENETIC REGULATION;
ALZHEIMERS-DISEASE;
COGNITIVE FUNCTION;
ALLOSTATIC LOAD;
CHILDREN;
STRESS;
GENE;
D O I:
10.1038/mp.2011.53
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Accelerated telomere length attrition has been associated with psychological stress and early adversity in adults; however, no studies have examined whether telomere length in childhood is associated with early experiences. The Bucharest Early Intervention Project is a unique randomized controlled trial of foster care placement compared with continued care in institutions. As a result of the study design, participants were exposed to a quantified range of time in institutional care, and represented an ideal population in which to examine the association between a specific early adversity, institutional care and telomere length. We examined the association between average relative telomere length, telomere repeat copy number to single gene copy number (T/S) ratio and exposure to institutional care quantified as the percent of time at baseline (mean age 22 months) and at 54 months of age that each child lived in the institution. A significant negative correlation between T/S ratio and percentage of time was observed. Children with greater exposure to institutional care had significantly shorter relative telomere length in middle childhood. Gender modified this main effect. The percentage of time in institutional care at baseline significantly predicted telomere length in females, whereas the percentage of institutional care at 54 months was strongly predictive of telomere length in males. This is the first study to demonstrate an association between telomere length and institutionalization, the first study to find an association between adversity and telomere length in children, and contributes to the growing literature linking telomere length and early adversity. Molecular Psychiatry ( 2012) 17, 719-727; doi:10.1038/mp.2011.53; published online 17 May 2011
机构:
Univ Georgia, Athens, GA 30602 USAUniv Georgia, Athens, GA 30602 USA
Beach, Steven R. H.
Brody, Gene H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Georgia, Athens, GA 30602 USAUniv Georgia, Athens, GA 30602 USA
Brody, Gene H.
Todorov, Alexandre A.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Dept Psychiat, St Louis, MO USAUniv Georgia, Athens, GA 30602 USA
Todorov, Alexandre A.
Gunter, Tracy D.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Sch Med, Dept Neurol & Psychiat, St Louis, MO USAUniv Georgia, Athens, GA 30602 USA
Gunter, Tracy D.
Philibert, Robert A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Univ Iowa, Neurosci Program, Iowa City, IA USA
Univ Iowa, Genet Program, Iowa City, IA USAUniv Georgia, Athens, GA 30602 USA
机构:
Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Drury, Stacy S.
Theall, Katherine P.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Baton Rouge, LA 70803 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Theall, Katherine P.
Smyke, Anna T.
论文数: 0引用数: 0
h-index: 0
机构:Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Smyke, Anna T.
Keats, Bronya J. B.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Baton Rouge, LA 70803 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Keats, Bronya J. B.
Egger, Helen L.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Durham, NC USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Egger, Helen L.
Nelson, Charles A.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Childrens Hosp, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Nelson, Charles A.
Fox, Nathan A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, College Pk, MD 20742 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Fox, Nathan A.
Marshall, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Temple Univ, Philadelphia, PA 19122 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Marshall, Peter J.
Zeanah, Charles H.
论文数: 0引用数: 0
h-index: 0
机构:Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
机构:
Univ Georgia, Athens, GA 30602 USAUniv Georgia, Athens, GA 30602 USA
Beach, Steven R. H.
Brody, Gene H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Georgia, Athens, GA 30602 USAUniv Georgia, Athens, GA 30602 USA
Brody, Gene H.
Todorov, Alexandre A.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Dept Psychiat, St Louis, MO USAUniv Georgia, Athens, GA 30602 USA
Todorov, Alexandre A.
Gunter, Tracy D.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Sch Med, Dept Neurol & Psychiat, St Louis, MO USAUniv Georgia, Athens, GA 30602 USA
Gunter, Tracy D.
Philibert, Robert A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA
Univ Iowa, Neurosci Program, Iowa City, IA USA
Univ Iowa, Genet Program, Iowa City, IA USAUniv Georgia, Athens, GA 30602 USA
机构:
Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Drury, Stacy S.
Theall, Katherine P.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Baton Rouge, LA 70803 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Theall, Katherine P.
Smyke, Anna T.
论文数: 0引用数: 0
h-index: 0
机构:Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Smyke, Anna T.
Keats, Bronya J. B.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Baton Rouge, LA 70803 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Keats, Bronya J. B.
Egger, Helen L.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Durham, NC USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Egger, Helen L.
Nelson, Charles A.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Childrens Hosp, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Nelson, Charles A.
Fox, Nathan A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland, College Pk, MD 20742 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Fox, Nathan A.
Marshall, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Temple Univ, Philadelphia, PA 19122 USATulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA
Marshall, Peter J.
Zeanah, Charles H.
论文数: 0引用数: 0
h-index: 0
机构:Tulane Univ, Hlth Sci Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA