CD81 Expression in the Differential Diagnosis of Chronic Lymphocytic Leukemia

被引：4

作者：

Afacan-Ozturk, Hacer B. ^{[1
]}

Falay, Mesude ^{[2
]}

Albayrak, Murat ^{[1
]}

Yildiz, Abdulkerim ^{[1
]}

Ozturk, Cigdem Pala ^{[1
]}

Maral, Senem ^{[1
]}

Ozet, Gulsum ^{[2
]}

机构：

[1] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Hematol, Ankara, Turkey

[2] Univ Hlth Sci, Numune Training & Res Hosp, Dept Hematol, Ankara, Turkey

来源：

CLINICAL LABORATORY | 2019年 / 65卷 / 03期

关键词：

CD81; chronic lymphocytic leukemia; MANTLE CELL LYMPHOMA; SCORING SYSTEM; LYMPHOPROLIFERATIVE DISORDERS; FLOW-CYTOMETRY; CD23; CLASSIFICATION; GUIDELINES; CD38;

D O I：

10.7754/Clin.Lab.2018.180802

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Immunophenotyping has a central role in CLL. However, CLL is a very heterogenous disease, both morphologically and immunophenotypically; thus, its diagnosis may prove a challenge. We investigated CD81 ex-pression in the differential diagnosis of CLL and MCL. Methods: We retrospectively examined CD81 expression with 8 color Multiparameter Flow cytometry devices in 101 CLL and 19 MCL cases. Results: We found negative CD81 expression in CLL cases whereas it was positive in MCL cases. Conclusions: Our results suggest that CD81 may be a valuable marker for the differential diagnosis of CLL. We are of the opinion that it should be definitely included in the diagnostic algorithm for CLL.

引用

页码：313 / 317

页数：5

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